Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diphenylamine-derived bis-hydroxyamide catalyzed asymmetric borane reduction of prochiral ketones
, 2009 A series of bis-hydroxyamides were synthesized from diphenylamine-2,2'-dicarboxylic acid and chiral aminoalcohols. Their catalytic activity in asymmetric borane reduction was investigated.
Liu, Han +3 more
core +1 more source
Nature Communications, 2019 Outer radial glial cells (oRGs) are undifferentiated cells that divide in the subventricular zone during neurodevelopment, but the underlying mechanisms are not fully understood.
T. Kawaue +10 more
doaj +1 more source
Psychosocial aspects of domestic violence
Ricerca Psicoanalitica, 2020 The work carried out and the experiences of the clinicians show that the phenomenon of domestic violence is much more evident than what is believed in "normal" family and social contexts.
Ana Luisa Botto
doaj +1 more source
Model development for the analysis of reducing voltage asymmetry methods in power supply systems
Известия высших учебных заведений: Проблемы энергетики, 2022 THE PURPOSE. To consider the issues of ensuring the quality of electricity in power supply systems. Show that the quality of electrical energy during the operation of power supply systems in certain cases may be violated, including due to uneven loading ...
V. I. Biryulin, D. V. Kudelina
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells
Nature Communications, 2016 The molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises ...
Mayumi Okamoto +7 more
doaj +1 more source
Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update
Cells, 2019 Thirty-five years ago, we described fragmentation of the mitochondrial population in a living cell into small vesicles (mitochondrial fission). Subsequently, this phenomenon has become an object of general interest due to its involvement in the process ...
Dmitry B. Zorov +9 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Functional correlates of positional and gender-specific renal asymmetry in Drosophila [PDF]
, 2012 In humans and other animals, the internal organs are positioned asymmetrically in the body cavity, and disruption of this body plan can be fatal in humans.
Chintapalli, Venkateswara R +7 more
core +5 more sources