Results 41 to 50 of about 1,107,456 (300)

A Look at the Importance of Chirality in Drug Activity: Some Significative Examples

open access: yesApplied Sciences, 2022
Chirality plays an important role in the development of many pharmaceuticals, being a general property of ‘handedness’; nevertheless, a large number of pharmaceuticals are still marketed and administered as racemates.
Jessica Ceramella   +7 more
doaj   +1 more source

Phenomenology of the Flavor-Asymmetry in the Light-Quark Sea of the Nucleon [PDF]

open access: yes, 2000
A phenomenological ansatz for the flavor-asymmetry of the light sea distributions of the nucleon, based on the Pauli exclusion principle, is proposed.
E. REYA   +6 more
core   +4 more sources

A parietal biomarker for ADHD liability:As predicted by The Distributed Effects Perspective Model of ADHD

open access: yesFrontiers in Psychiatry, 2015
Background: We previously hypothesized that poor task-directed sensory information processing should be indexed by increased weighting of right hemisphere (RH) biased attention and visuo-perceptual brain functions during task operations, and have ...
T. Sigi eHale   +7 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development

open access: yesNature Communications, 2019
Outer radial glial cells (oRGs) are undifferentiated cells that divide in the subventricular zone during neurodevelopment, but the underlying mechanisms are not fully understood.
T. Kawaue   +10 more
doaj   +1 more source

Psychosocial aspects of domestic violence

open access: yesRicerca Psicoanalitica, 2020
The work carried out and the experiences of the clinicians show that the phenomenon of domestic violence is much more evident than what is believed in "normal" family and social contexts.
Ana Luisa Botto
doaj   +1 more source

Model development for the analysis of reducing voltage asymmetry methods in power supply systems

open access: yesИзвестия высших учебных заведений: Проблемы энергетики, 2022
THE PURPOSE. To consider the issues of ensuring the quality of electricity in power supply systems. Show that the quality of electrical energy during the operation of power supply systems in certain cases may be violated, including due to uneven loading ...
V. I. Biryulin, D. V. Kudelina
doaj   +1 more source

Lepton asymmetry and the cosmic QCD transition

open access: yes, 2009
We study the influence of lepton asymmetry on the evolution of the early Universe. The lepton asymmetry $l$ is poorly constrained by observations and might be orders of magnitude larger than the baryon asymmetry $b$, $|l|/b \leq 2\times 10^8$.
  +13 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

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