Results 51 to 60 of about 1,107,456 (300)
Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells
Nature Communications, 2016 The molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises ...
Mayumi Okamoto +7 more
doaj +1 more source
Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update
Cells, 2019 Thirty-five years ago, we described fragmentation of the mitochondrial population in a living cell into small vesicles (mitochondrial fission). Subsequently, this phenomenon has become an object of general interest due to its involvement in the process ...
Dmitry B. Zorov +9 more
doaj +1 more source
CP Asymmetry in Charged Higgs Decays to Chargino-Neutralino
, 2007 We analyze the charge-parity (CP) asymmetry in the charged Higgs boson decays to chargino-neutralino pairs, H^- -> chargino_i + neutralino_j. We show first that these modes have a large branching ratio for m_H^- > 600 GeV. We use Cutkosky rules to obtain
D. Chang +8 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Frontiers in Communications and Networks, 2021 As the memristor device is asymmetrical in nature, it is not a bilateral element like the resistor in terms of circuit functionality. Thus, it causes hindrance in some memristor-based applications such as in cellular nonlinear network neighborhood ...
Aliyu Isah +4 more
doaj +1 more source
Divergence of the isospin-asymmetry expansion of the nuclear equation of state in many-body perturbation theory [PDF]
, 2016 The isospin-asymmetry dependence of the nuclear matter equation of state obtained from microscopic chiral two- and three-body interactions in second-order many-body perturbation theory is examined in detail. The quadratic, quartic and sextic coefficients
Holt, Jeremy W. +2 more
core +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Psychiatry, 2018 Background: Subjective cognitive decline (SCD) may be the first clinical sign of Alzheimer's disease (AD). SCD individuals with normal cognition may already have significant medial temporal lobe atrophy.
Ling Yue +15 more
doaj +1 more source