Results 71 to 80 of about 3,669,328 (301)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

A Numerical Comparison for a Discrete HIV Infection of CD4+ T-Cell Model Derived from Nonstandard Numerical Scheme

Journal of Applied Mathematics, 2013
A nonstandard numerical scheme has been constructed and analyzed for a mathematical model that describes HIV infection of CD4+ T cells. This new discrete system has the same stability properties as the continuous model and, particularly, it preserves the
Mevlüde Yakıt Ongun, İlkem Turhan
doaj   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

The performance analysis of amplitude suppression of sinusoidal hindrances

Известия высших учебных заведений России: Радиоэлектроника, 2015
The problem of the performance analysis of non-Gaussian amplitude suppression with distribution of envelope is considered. The asymptotic values of the characteristics are investigated.
V. A. Danilov, L. V. Danilova
doaj  

Spatiotemporal averaging resolution of high importance within Earth-observation-based light use efficiency models of gross primary production

Science of Remote Sensing
Gross primary production (GPP) of the vegetation is the largest carbon exchange process of the global carbon cycle. Currently, within satellite-based remote sensing, GPP is generally modelled using linear light use efficiency models where GPP is related ...
Torbern Tagesson, Paul Senty, Ousmane Diatta, Zhanzhang Cai, Aleksander Wieckowski, Ousmane Ndiaye, Jonas Ardö   +6 more
doaj   +1 more source

Asymptotic efficiency of restart and checkpointing

CoRR, 2018
Many tasks are subject to failure before completion. Two of the most common failure recovery strategies are restart and checkpointing. Under restart, once a failure occurs, it is restarted from the beginning. Under checkpointing, the task is resumed from the preceding checkpoint after the failure.
openaire   +3 more sources

Asymptotic Efficiency of the OLS Estimator with Singular Limiting Sample Moment Matrices [PDF]

This paper presents a time series model that has an asymptotically efficient ordinary least squares (OLS) estimator, irrespective of the singularity of its limiting sample moment matrices.
Yoshimasa Uematsu
core  

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

Advanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri, A. Mangiarotti, C. N. Z. Schmitt, R. Dimova   +3 more
wiley   +1 more source

Report of the Energy Efficiency Board. 2011.

, 2011
Annual; Began with 2010.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core  

CLTs and asymptotic variance of time-sampled Markov chains [PDF]

, 2011
For a Markov transition kernel P and a probability distribution μ on nonnegative integers, a time-sampled Markov chain evolves according to the transition kernel Pμ = Σkμ(k)Pk.
Łatuszyński, Krzysztof, Krzysztof Łatuszyński, Roberts, Gareth O., Gareth O. Roberts   +3 more
core   +1 more source