Results 31 to 40 of about 63,489 (260)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Heat Equation Solution Near the Interface Between Two Media

Моделирование и анализ информационных систем, 2017
Physical  phenomena  that arise near the boundaries  of media with different characteristics, for example,  changes in temperature at  the  water-air interface,  require  the  creation  of models for their  adequate description. Therefore,  when setting 
Natalia T. Levashova, Olga A. Nikolaeva
doaj   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane, Salama Makni, Mourad Kchaou, Ahmed El Hajjaji   +3 more
wiley   +1 more source

Existence and Stability of the Periodic Solution with an Interior Transitional Layer in the Problem with a Weak Linear Advection

Моделирование и анализ информационных систем, 2018
In the paper, we study a singularly perturbed periodic in time problem for the parabolic reaction-advection-diffusion equation with a weak linear advection. The case of the reactive term in the form of a cubic nonlinearity is considered.
Nikolay N. Nefedov, Egor Ig. Nikulin
doaj   +1 more source

Applications of OHAM and MOHAM for Fractional Seventh-Order SKI Equations

Journal of Applied Mathematics, 2021
In this article, a comparative study between optimal homotopy asymptotic method and multistage optimal homotopy asymptotic method is presented. These methods will be applied to obtain an approximate solution to the seventh-order Sawada-Kotera Ito ...
Jafar Biazar, Saghi Safaei
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Generalized Pad´e approximations in the problem of calculating the period of a relaxation cycle

Вестник Самарского университета: Естественнонаучная серия
When solving many applied problems, it is necessary to calculate the bifurcation values of the parameters of a dynamical system. These values must be determined with a high degree of accuracy. As a rule, bifurcation parameter values are found in the form
E. S. Dolgova
doaj   +1 more source

Asymptotic stability of linear multistep methods and Runge-Kutta methods for homogeneous differential-algebraic equations with rectangular coefficients

上海师范大学学报. 自然科学版, 2021
This paper is concerned with the asymptotic stability of numerical methods applied to linear differential-algebraic equations. The coefficient matrices of the system are constant rectangular matrices.
SUN Leping
doaj   +1 more source

Distinct Microstructural Characteristic Lengths Defining Notch Fatigue Crack Initiation and Propagation, and Defect Tolerance in Advanced Steels

Advanced Engineering Materials, EarlyView.
Schematic representation of modes of microcrack nucleation, growth and temporary arrestment at different boundaries, with the criteria for crack propagation in three scenarios: (1) large notch, (2) defect/small sharp notch, and (3) long crack. This work revisits and integrates results on the fatigue behavior of advanced bainitic steels (in particular ...
Lucia Morales‐Rivas
wiley   +1 more source