Results 251 to 260 of about 33,965 (276)
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European Journal of Cancer, 2014
Neuroblastoma (NB) is a paediatric solid tumour which originates from sympathetic nervous tissues. Deletions in chromosome 1p are frequently found in unfavourable NBs and are correlated with v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) amplification; however, it remains to be elucidated how the 1p loss contributes to
Yohko, Yamaguchi +9 more
openaire +2 more sources
Neuroblastoma (NB) is a paediatric solid tumour which originates from sympathetic nervous tissues. Deletions in chromosome 1p are frequently found in unfavourable NBs and are correlated with v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) amplification; however, it remains to be elucidated how the 1p loss contributes to
Yohko, Yamaguchi +9 more
openaire +2 more sources
2012
The ability of cells to maintain their genomic integrity is essential to the prevention of cancer development. Double-strand breaks (DSBs), the most harmful type of lesion to DNA, are sensed by ataxia-telangiectasia mutated (ATM) protein in association with the MRE11-RAD50-NBS1 complex. The ATM kinase, which is mutated in ataxia-telangiectasia disorder,
Javier G. Pizarro +7 more
openaire +1 more source
The ability of cells to maintain their genomic integrity is essential to the prevention of cancer development. Double-strand breaks (DSBs), the most harmful type of lesion to DNA, are sensed by ataxia-telangiectasia mutated (ATM) protein in association with the MRE11-RAD50-NBS1 complex. The ATM kinase, which is mutated in ataxia-telangiectasia disorder,
Javier G. Pizarro +7 more
openaire +1 more source
2007
Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase that plays a central role in controlling the cellular response to DNA double-strand breaks caused by ionizing radiation. Ionizing radiation induces the autophosphorylation of ATM on serine 1981; however, the precise mechanisms that regulate ATM autophosphorylation are not fully ...
Aaron A, Goodarzi +3 more
openaire +2 more sources
Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase that plays a central role in controlling the cellular response to DNA double-strand breaks caused by ionizing radiation. Ionizing radiation induces the autophosphorylation of ATM on serine 1981; however, the precise mechanisms that regulate ATM autophosphorylation are not fully ...
Aaron A, Goodarzi +3 more
openaire +2 more sources
Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening.
American journal of human genetics, 1996We have examined the distal half of the ataxia-telangiectasia (A-T) gene transcript for truncation mutations in 48 A-T affecteds. We found 21 mutations; 4 of the mutations were seen in more than one individual. Genotyping of the individuals sharing mutations, by using nearby microsatellite markers, established that three of the four groups shared ...
M, Telatar +9 more
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Composition and enzymatic activities of ataxia-telangiectasia mutated (ATM) protein complexes
2022openaire +1 more source
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
Nature Reviews Molecular Cell Biology, 2008Martin F Lavin
exaly
Antisense oligonucleotide therapy for spinocerebellar ataxia type 2
Nature, 2017Daniel R Scoles +2 more
exaly
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia
Nature Medicine, 2004Qinwen Mao, Harry T Orr, Robert M Kotin
exaly