Results 231 to 240 of about 41,016 (281)

Inhibiting the DNA damage repair of HNSCC cells in combination with normo-fractionated radiotherapy influences clonogenicity, senescence and expression of NK cell activation markers. [PDF]

Sci Rep
Jost T, Wachter M, Meidenbauer J, Fietkau R, Gaipl US.   +4 more
europepmc   +1 more source

Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia. [PDF]

Cell Death Dis
Vinciguerra M, El Kharef C, Bruhn C, Falbo L, Milanese C, Audano M, Beznoussenko GV, Mironov AA, Delia D, Foiani M, Mastroberardino PG, Mitro N, Costanzo V.   +12 more
europepmc   +1 more source

MRI and Biomarkers in Early Detection of Pulmonary Changes in Ataxia-Telangiectasia. [PDF]

Med Sci Monit
Grzywa-Czuba R, Dmeńska H, Jurkiewicz E, Gregorek H, Pietrucha B.   +4 more
europepmc   +1 more source

Assessing Determinants of Response to PARP Inhibition in Germline <i>ATM</i> Mutant Melanoma. [PDF]

Int J Mol Sci
Allavena E, Croce M, Dalmasso B, Profumo C, Rigo V, Andreotti V, Vanni I, Pellegrino B, Musolino A, Campanini N, Bruno W, Mastracci L, Zoppoli G, Tanda ET, Spagnolo F, Ghiorzo P, Pastorino L.   +16 more
europepmc   +1 more source

Role of LINE-1 in the nervous system and neurological disorders. [PDF]

Chin Med J (Engl)
Hu H, Lu X, Zhong R, Liu X, Wei J, Duan C, Sun N.   +6 more
europepmc   +1 more source

Therapeutic Targeting of DNA Damage Response Pathways in <i>TP53</i>- and <i>ATM</i>-Mutated Tumors. [PDF]

Brain Tumor Res Treat
Shim YJ.
europepmc   +1 more source

Phase 1 clinical trial of the ataxia telangiectasia and Rad3-related inhibitor berzosertib with irinotecan in patients with advanced solid tumors (ETCTN 9938). [PDF]

Cancer
Villaruz LC, Jin J, Wang H, Lee JJ, Luke JJ, Rhee JC, Waqar SN, Shapiro GI, Cleary J, Davar D, Burns TF, Verma R, Amin M, Appleman L, Ciombor KK, Davis EJ, Riess JW, Dees EC, Kim EJ, Cardin D, Guo J, Christner SM, Deppas J, Parise AM, Schmitz JC, Guerrouahen BS, Suchko M, Contreras A, Li L, Ferry-Galow KV, Chang TC, Jiwani S, Bakkenist CJ, Chu E, Gore SD, Beumer JH.   +35 more
europepmc   +1 more source

DNA Damage and Repair in Ovarian Cancer: Focus on MicroRNAs. [PDF]

Cancers (Basel)
Arczewska KD, Piekiełko-Witkowska A.
europepmc   +1 more source

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miR‐26a attenuates cardiac apoptosis and fibrosis by targeting ataxia–telangiectasia mutated in myocardial infarction

Journal of Cellular Physiology, 2020
Apoptosis and fibrosis play a vital role in myocardial infarction (MI) induced tissue injury. Although microRNAs have been the focus of many studies on cardiac apoptosis and fibrosis in MI, the detailed effects of miR‐26a is needed to further understood.
Ming-Hsien Chiang, Chan‐Jung Liang, Lung-Chun Lin, Yi-Fan Yang, Ching-Chang Huang, Ying-Hsien Chen, H. Kao, Yu-Chen Chen, S. Ke, Chiang-Wen Lee, Mao-Shin Lin, Yuh-Lien Chen   +11 more
semanticscholar   +1 more source

Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy

Current Drug Targets, 2016
Genotoxic anticancer drugs explicate their effects damaging DNA, thus triggering a coordinated signal-transduction network called DNA Damage Response (DDR). Ataxia Telangiectasia Mutated (ATM) protein plays a central role in this response: activated by DNA damage, ATM phosphorylates itself and downstream effectors that arrest cell cycle allowing for ...
Donatella, Vecchio, Guido, Frosina
openaire   +2 more sources