Results 251 to 260 of about 41,016 (281)

Cell Cycle Control by Ataxia Telangiectasia Mutated Protein Through Regulating Retinoblastoma Protein Phosphorylation

2012
The ability of cells to maintain their genomic integrity is essential to the prevention of cancer development. Double-strand breaks (DSBs), the most harmful type of lesion to DNA, are sensed by ataxia-telangiectasia mutated (ATM) protein in association with the MRE11-RAD50-NBS1 complex. The ATM kinase, which is mutated in ataxia-telangiectasia disorder,
Javier G. Pizarro, Antoni Camins, Felix Junyent, Ester Verdaguer, Carme Auladell, Carlos Beas-Zarate, Mercè Pallàs, Jaume Folch   +7 more
openaire   +1 more source

Utilizing Protein Phosphatase Inhibitors to Define PP2A as a Regulator of Ataxia-Telangiectasia Mutated

2007
Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase that plays a central role in controlling the cellular response to DNA double-strand breaks caused by ionizing radiation. Ionizing radiation induces the autophosphorylation of ATM on serine 1981; however, the precise mechanisms that regulate ATM autophosphorylation are not fully ...
Aaron A, Goodarzi, Pauline, Douglas, Greg B G, Moorhead, Susan P, Lees-Miller   +3 more
openaire   +2 more sources

Ataxia-telangiectasia: mutations in ATM cDNA detected by protein-truncation screening.

American journal of human genetics, 1996
We have examined the distal half of the ataxia-telangiectasia (A-T) gene transcript for truncation mutations in 48 A-T affecteds. We found 21 mutations; 4 of the mutations were seen in more than one individual. Genotyping of the individuals sharing mutations, by using nearby microsatellite markers, established that three of the four groups shared ...
M, Telatar, Z, Wang, N, Udar, T, Liang, E, Bernatowska-Matuszkiewicz, M, Lavin, Y, Shiloh, P, Concannon, R A, Good, R A, Gatti   +9 more
openaire   +1 more source

Concordance of ATM (Ataxia Telangiectasia Mutated) Immunohistochemistry between Biopsy or Metastatic Tumor Samples and Primary Tumors in Gastric Cancer Patients

Pathobiology (Basel), 2013
H. Kim, Min A. Kim, D. Hodgson, C. Harbron, R. Wellings, M. O’Connor, C. Womack, Xiaolu Yin, Y. Bang, S. Im, B. Lee, W. Kim   +11 more
semanticscholar   +1 more source

Cellular functions of the protein kinase ATM and their relevance to human disease

Nature Reviews Molecular Cell Biology, 2021
Ji-Hoon Lee, Tanya T Paull
exaly  

Ku, Artemis, and ataxia-telangiectasia-mutated: signalling networks in DNA damage.

International Journal of Biochemistry and Cell Biology, 2008
T. Morio, Hyeyoung Kim
semanticscholar   +1 more source

Composition and enzymatic activities of ataxia-telangiectasia mutated (ATM) protein complexes

2022
openaire   +1 more source

ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis.

Biochemical Society Transactions, 2001
Y. Shiloh
semanticscholar   +1 more source

Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

Lancet, The, 1999
Tatjana Stankovic, Grant Stewart, Paul Moss   +2 more
exaly  

Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1.

Methods in Enzymology, 2006
Ji‐Hoon Lee, T. Paull
semanticscholar   +1 more source