Results 131 to 140 of about 13,262,735 (197)

Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3. [PDF]

Parkinsonism Relat Disord, 2021
Koike Y, Jansen-West KR, Hanna Al-Shaikh R, Carlomagno Y, Song Y, Dunmore JA, LeDoux MS, Friedman JH, Pena AB, Uitti RJ, Zaremba J, van Gerpen JA, Pfeiffer RF, Veerappan V, Aiba I, Hashimoto R, Giles SS, Shah JS, Tipton PW, Huang JF, Wierenga KJ, Aasly J, Fryer JD, Petrucelli L, Wszolek ZK, Prudencio M.   +25 more
europepmc   +1 more source

Valproic acid does not prevent aggregation of mutant Ataxin-3 protein.

, 2013
(A) Fluorescent microscopy showing the expression of ataxin-3-68Q-GFP protein (green) and DAPI stained nucleus (blue) in the same HEK293 T cells. In the picture, significant diffuse staining of ataxin-3 protein can be detectable both in the cytoplasm and
Yafang Zhou (286594), Zhao Chen (92571), Jiping Yi (286592), Hong Jiang (79543), Beisha Tang (77106), Weiwei Han (286593), Dandan Jia (286595), Li Zhang (8200)   +7 more
core   +1 more source

Investigation of the multi-domain aggregation mechanism of ataxin-3

, 2010
Spinocerebellar Ataxia Type 3 (SCA3) is one of nine polyglutamine (polyQ) diseases which are all characterized by progressive neuronal dysfunction. A hallmark of these diseases is the presence of neuronal inclusions which contain aggregated polyQ protein,
Saunders, Helen Michelle
core  

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates. [PDF]

Sci Rep, 2021
Yue HW, Hong JY, Zhang SX, Jiang LL, Hu HY.   +4 more
europepmc   +1 more source

Pathogenese der spinozerebellären Ataxie Typ 3 : Einfluss der CK2-abhängigen Phosphorylierung auf die zelluläre Lokalisation und Funktion von Ataxin-3 [PDF]

, 2008
Bei den autosomal-dominant vererbten spinozerebellären Ataxien handelt es sich um neurodegenerative Erkrankungen, die durch einen selektiven Verlust von Nervenzellen im zentralen Nervensystem gekennzeichnet sind.
Müller, Thorsten
core  

PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study. [PDF]

J Neurol, 2021
Gonsior K, Kaucher GA, Pelz P, Schumann D, Gansel M, Kuhs S, Klockgether T, Forlani S, Durr A, Hauser S, Rattay TW, Synofzik M, Hengel H, Schöls L, Rieß OH, Hübener-Schmid J.   +15 more
europepmc   +1 more source

Aggregation and nuclear expression of the spinocerebellar ataxia type 3 gene product, ataxin-3

, 1999
Spinocerebellar ataxia type 3 or Machado-Joseph disease (SCA3/MID) is a member of the CAG/polyglutamine disease family. In this family of disorders a CAG repeat expansion occurs within the coding region of the diseased gene, resulting in expression of ...
Perez, Matthew Kurt
core  

The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina. [PDF]

Cell Rep, 2020
Toulis V, García-Monclús S, de la Peña-Ramírez C, Arenas-Galnares R, Abril JF, Todi SV, Khan N, Garanto A, Costa MDC, Marfany G.   +9 more
europepmc   +1 more source

Observation of liquid-liquid phase separation of ataxin-3 and quantitative evaluation of its concentration in a single droplet using Raman microscopy. [PDF]

Chem Sci, 2021
Murakami K, Kajimoto S, Shibata D, Kuroi K, Fujii F, Nakabayashi T.   +5 more
europepmc   +1 more source

Identification and caracterization of ataxin-3 Molecular Interactors.

, 2007
Doutoramento em Ciências ...
openaire   +2 more sources