Results 131 to 140 of about 19,027,943 (182)

The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3. [PDF]

Biophys J, 2018
Sicorello A, Kelly G, Oregioni A, Nováček J, Sklenář V, Pastore A.   +5 more
europepmc   +1 more source

Genetic polymorphisms in ataxin-3 and liver cirrhosis risk related to aflatoxin B1. [PDF]

Oncotarget, 2018
Wang XZ, Huang XY, Yao JG, Wang C, Xia Q, Long XD.   +5 more
europepmc   +1 more source

Autophagy mediates SUMO-induced degradation of a polyglutamine protein ataxin-3. [PDF]

Anim Cells Syst (Seoul), 2017
Hwang SP, Lee DH.
europepmc   +1 more source

The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. [PDF]

PLoS Biol, 2016
Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C, Wang Q, Tang TS.   +13 more
europepmc   +1 more source

Starvation-induced HSC70 O-GlcNAcylation activates chaperone-mediated autophagy. [PDF]

J Biol Chem
Xu N, Wang X, Zhang J, Zhao J, Yan S, Zhou W, Chi W, Li J.   +7 more
europepmc   +1 more source

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Trehalose prevents the formation of aggregates of mutant ataxin-3 and reduces soluble ataxin-3 protein levels in an SCA3 cell model.

Neuroscience
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder caused by mutant ataxin-3 with an abnormally expanded polyQ tract and is the most common dominantly inherited ataxia worldwide.
Zijian Wang, Min Wang, Yuhang Huang, Zhiwei Ma, Wenjing Gao, Tian-Fu Zhang, Jiexin Deng, Xiao-Bing Cheng, Yingxun Liu, Bo Wang, Ying Qi, Min Yang, Fengqin He   +12 more
semanticscholar   +3 more sources

Phosphorylation of ataxin-3 by glycogen synthase kinase 3β at serine 256 regulates the aggregation of ataxin-3

Biochemical and Biophysical Research Communications, 2007
Machado-Joseph disease (MJD) is a dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract in MJD-1 gene product, ataxin-3. Recently, studies show that phosphorylation of polyglutamine disease proteins, such as huntingtin, ataxin-1 and DRPLA, plays an important role in regulating pathogenesis.
Guanghui Wang, Nobuyuki Nukina, Xiaochuan Ma   +2 more
exaly   +3 more sources

Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2023
BACKGROUND Pancreatic cancer is a common digestive system cancer and one of the most lethal malignancies worldwide. Ataxin-3 (ATXN3) protein is a deubiquitinating enzyme implicated in the occurrence of diverse human cancers.
Xin Wu, Xin Zhang, Peng Liu, Yao Wang
semanticscholar   +1 more source