The effect of apixaban on the pharmacokinetics of digoxin and atenolol in healthy subjects
Charles Frost,1 Yan Song,1 Zhigang Yu,2 Jessie Wang,3 Lois S Lee,4 Alan Schuster,5 Allyson Pollack,1 Frank LaCreta1 1Exploratory Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA; 2Medical Sciences, Amgen Asia R&D Center ...
Frost C +7 more
doaj
67-year-old female who was referred from her general practitioner because of uncontrolled right popliteal knee pain which was very severe and continuously deteriorating. She could not bend her knee and sleep because of the pain.
Bertuello, Isaac, Bonnici, Maria
core
Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk [PDF]
Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgroup ...
A Algra +6 more
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Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]
Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V +3 more
core +2 more sources
Personalized medicine—a modern approach for the diagnosis and management of hypertension [PDF]
The main goal of treating hypertension is to reduce blood pressure to physiological levels and thereby prevent risk of cardiovascular disease and hypertension-associated target organ damage.
Borghi, Claudio +5 more
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Development and Evaluation of Gastroretentive Atenolol Tablets
The low oral bioavailability of atenolol is primarily because of its poor absorption from the lower gastrointestinal tract. Gastroretentive dosage forms provide an opportunity to deliver the drug with absorption window in the proximal part of the GIT ...
Rachna kumria +4 more
doaj +1 more source
Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function [PDF]
Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown.
Fitts, Robert H., Wang, Xinrui
core +1 more source
Letter: Once-daily atenolol for hypertension. [PDF]
E. M. M. Besterman
openalex +1 more source
Objectives: This meta-analysis of randomized parallel controlled trials was designed to compare the efficacy of atenolol with angiotensin-converting enzyme inhibitors (ACEIs) in changing pulse wave velocity (PWV), peripheral blood pressure and heart rate
Hong Xie +4 more
doaj +1 more source
Ocular hypotensive effect of atenolol (Tenormin, I.C.I.). A new beta-adrenergic blocker. [PDF]
M. Elliot, P M Cullen, C I Phillips
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