Results 141 to 150 of about 620,434 (340)

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

Advanced Science, EarlyView.
A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Babatunde, Adeel Ahmed, Wilmara Salgado‐Pabon, David J Beebe, Sheena C. Kerr   +5 more
wiley   +1 more source

Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

Journal of Lipid Research, 1994
Using ion exchange high pressure liquid chromatography, total plasma low density lipoprotein (LDL) from 30 hypercholesterolemic and 10 normocholesterolemic cynomolgus monkeys was subfractionated into unmodified LDL (n-LDL) and more negatively charged LDL
H.N. Hodis, D.M. Kramsch, P. Avogaro, G. Bittolo-Bon, G. Cazzolato, J. Hwang, H. Peterson, A. Sevanian   +7 more
doaj  

Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis

Intensive Care Medicine Experimental
Introduction Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcome.
Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud, Patricia C. Liaw   +11 more
doaj   +1 more source

Relationship of Degree of Atherosclerosis of Internal Carotid System in the Brain of Women to Age and Coronary Atherosclerosis [PDF]

, 1958
Malcolm D. Winter, George P. Sayre, Clark H. Millikan, Nelson W. Barker   +3 more
openalex   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

A compound heterozygote for lipoprotein lipase deficiency, Val69–>Leu and Gly188–>Glu: correlation between in vitro LPL activity and clinical expression.

Journal of Lipid Research, 1994
We analyzed the molecular defects in the lipoprotein lipase gene of a patient with type I hyperlipidemia suffering from recurrent pancreatitis, indicative for lipoprotein lipase deficiency.
T. Bruin, S. Tuzgöl, W.J. Mulder, A.E. van den Ende, H. Jansen, M.R. Hayden, J.J. Kastelein   +6 more
doaj  

Squalene Feeding in Experimental Atherosclerosis [PDF]

, 1954
David Kritchevsky, Arden W. Moyer, Walter C. Tesar, J. B. Logan, Raymond A. Brown, Gilbert Richmond   +5 more
openalex   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

EXPERIMENTAL ATHEROSCLEROSIS AND CARDIAC INFARCTS IN RATS [PDF]

, 1959
George F. Wilgram
openalex   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source