Results 131 to 140 of about 5,850,068 (304)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Endotypes: a customized approach to prevent atherosclerotic cardiovascular disease

Atherosclerotic cardiovascular diseases are the first cause of death and disability in Europe. Atherosclerosis is a silent killer: it progressively infiltrates the vascular wall and suddenly becomes evident with acute and potentially deadly events, such ...
Bruna Gigante
core   +2 more sources

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

Advanced Science, EarlyView.
Postoperative arteriovenous fistulas exhibit increased RBMS1 in vascular smooth muscle cells (VSMCs). In experimental AVFs, RBMS1 overexpression aggravates, whereas deletion attenuates, neointimal hyperplasia. RBMS1 binds MPZL1 mRNA and promotes exon 5 skipping to generate MPZL1‐Δ5, which interacts with G3BP1 to activate AKT, driving VSMC proliferation,
Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li, Zhenzhen Ma, Huimin Ma, Zihan Wang, Haihai Liang, Jundong Jiao   +14 more
wiley   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

The event-free survival of patients with atherosclerotic cardiovascular disease according to treatment group (A) before and (B) after PS matching.

, 2014
Atherosclerotic cardiovascular disease occurred more frequently in aspirin users versus non-users.
Han Ro (304022), Ae Jin Kim (610338), Kwang-Pil Ko (127398), Jae Hyun Chang (610341), Song Yi Han (610340), Hye Jin Lim (610339), Ji Yong Jung (610343), Wookyung Chung (610342), Hyun Hee Lee (13100)   +8 more
core   +1 more source

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1–NLRP3 Axis

Advanced Science, EarlyView.
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Hongseo Choi, Sukyoung Han, Jinho Kim, Ji Hye Han, Eunsu Kim, Yeonjeong Heo, Minju Lee, Jooyoung Lee, Heerim You, Soyoun Lee, Su‐Hee Han, Ilrok Yoon, Sung Anjeon, Hyerim Kang, Seungyeon Ryu, Hyun‐Ji Park, Eunha Kim, Chul Hwan Bang, Ji Hyun Lee, Josephine M. Egan, Jung‐Woong Kim, Eun Kyung Lee, Wook Kim   +22 more
wiley   +1 more source

Cardiovascular risk prediction: the old has given way to the new but at what risk-benefit ratio?

Research Reports in Clinical Cardiology, 2014
Joseph Yeboah Heart and Vascular Center of Excellence, Wake Forest University School of Medicine, Winston-Salem, NC, USA Abstract: The ultimate goal of cardiovascular risk prediction is to identify individuals in the population to whom the application ...
Yeboah J
doaj  

Macrophage GLUD1 is Essential for Redox Balance and Immune Homeostasis in Cardiac Injury

Advanced Science, EarlyView.
Excessive free radical production and dysregulated immune responses are key contributors to myocardial ischemia‐reperfusion (IR) injury. Macrophage GLUD1 activity safeguards against HIF‐1α accumulation and maladaptive responses to IR‐induced ROS production.
Tingting Jin, Chaojie Lai, Qingyan Zhou, Ruilin Wang, Yiping Tong, Wentao Chen, Nikola Rabrenovic, Tingyu Zhang, Xinrong Ren, Chengchen Huang, Jiawen Chen, Ran Li, Luyang Yu, Massimiliano Mazzone, Wenbin Zhang, Guosheng Fu, Min Shang   +16 more
wiley   +1 more source

Role of Lipids and Lipid Management Therapy Among Patients With Peripheral Artery Disease: A Reappraisal of the Current Evidence and Future Directions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Peripheral artery disease (PAD), defined by stenosis or occlusion of the extremities (particularly the lower extremities), affects 200 million individuals worldwide, including an estimated 7% of adults in the United States alone.
McCall Walker, Kayla A. Riggs, Anand Rohatgi, Joshua Beckman, Tayo Addo, Saket Girotra, Marc P. Bonaca, Ehrin Armstrong, Dharam J. Kumbhani   +8 more
doaj   +1 more source

Integrated Cardiovascular Disease Team Supporting Best Practice in Lipid Management

In Ireland, cardiovascular disease accounts for 32% of all deaths. There has been a steady decline in cardiovascular mortality from 1985 to 2006, with 24% being attributed to cholesterol reduction.
Brennan, Michelle
core