Results 111 to 120 of about 185,884 (310)

Trained immunity and atherosclerotic cardiovascular disease

Current Opinion in Lipidology, 2019
Purpose of review The two major challenges in cardiovascular medicine are to refine risk prediction and to improve pharmacological prevention and treatment. The concept of innate immune memory, which is called trained immunity, has the potential to improve clinical practice in these regards ...
openaire   +4 more sources

Statin-centric versus low-density lipoprotein-centric approach for atherosclerotic cardiovascular disease prevention: a Singapore perspective. [PDF]

, 2016
The link between cholesterol levels and atherosclerotic cardiovascular disease (ASCVD) is well-established. In Singapore, there is an increasing prevalence of risk factors for ASCVD. Like many Asian countries, Singapore's population is rapidly ageing and
P Yan, Waters, David D, CF Liew, EK Tan, JC Choo, Yan, Peter, Lau, Titus, Choo, Jason Chon Jun, T Lau, DD Waters, Tan, Eng Kiat Kevin, Liew, Choon Fong Stanley   +11 more
core   +1 more source

A high‐fat diet with vitamin D and propylthiouracil produces a pro‐atherogenic phenotype in rats

Animal Models and Experimental Medicine, EarlyView.
Male Sprague–Dawley rats received a cholesterol‐rich high‐fat diet supplemented with vitamin D and propylthiouracil for 11 weeks. The model induced dyslipidemia (increased total cholesterol/low‐density lipoprotein, decreased triglycerides), inflammation (increased interleukin‐6 and serum amyloid A), hypercalcemia, and reduced circulating endothelial ...
Angélique Lewies, Vitaris Kodogo, Johannes Frederik Wentzel, Francis Edwin Smit   +3 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease

, 2018
Several prospective epidemiological studies have shown that there is a clear inverse relationship between serum highdensity lipoprotein-cholesterol (HDL-C) concentrations and risk for coronary heart disease (CHD), even at low-density lipoprotein ...
Constantine E Kosmas, Andreas Sourlas, Eliscer Guzman, Kyriaki V Bouza, Ian Martinez, Frederick N Campos, Verenisse Torres, Peter D Montan   +7 more
core   +1 more source

Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis [PDF]

, 2010
Background: Circulating progenitor cells (CPC) contribute to the homeostasis of the vessel wall, and a reduced CPC count predicts cardiovascular morbidity and mortality.
Zeiher Andreas M., ZEIHER AM, Saula de Kreutzenberg, Ozaki Takenori, MARUYAMA S, Schmidt-Lucke, Caroline, Andreas M. Zeiher, Takenori Ozaki, Schmidt-Lucke Caroline, Avogaro, Angelo, WERNER N., Meigs, James, Nikos Werner, Meigs James, SCHMIDT LUCKE C, VIGILI DE KREUTZENBERG, SAULA, Shoichi Maruyama, Werner, Nikos, Fadini, Gian Paolo, Nickenig, Georg, OZAKI T, Taguchi Akihiko, DIMMELER S, Caroline Schmidt-Lucke, Werner Nikos, Taguchi, Akihiko, Andreas M Zeiher, MEIGS J, NICKENIG G, Maruyama Shoichi, Angelo Avogaro, Ozaki, Takenori, Gian Paolo Fadini, Fadini Gian Paolo, TAGUCHI A, Dimmeler Stefanie, Stefanie Dimmeler, Dimmeler, Stefanie, De Kreutzenberg, Saula, Maruyama, Shoichi, Akihiko Taguchi, Zeiher, Andreas M., James Meigs, Nickenig Georg, Avogaro Angelo, Georg Nickenig, de Kreutzenberg Saula   +46 more
core   +1 more source

The HCMV‐encoded miR‐UL36‐3p promotes angiogenesis of endothelial cells by downregulating FOXO3

Animal Models and Experimental Medicine, EarlyView.
This illustration shows the role of hcmv‐miR‐UL36‐3p in endothelial cell angiogenesis. During productive infection, endothelial cells express HCMV‐encoded miRNAs. Viral hcmv‐miR‐UL36‐3p promotes endothelial cell proliferation, migration, and capillary tube formation by directly targeting and downregulating FOXO3. The pro‐angiogenic activity of hcmv‐miR‐
Chen Wang, Mengyu Li, Guosheng Li, Hao Zhang, Cheng Wang, Chen‐Yu Zhang   +5 more
wiley   +1 more source

Renal artery stenosis-when to screen, what to stent? [PDF]

, 2014
Renal artery stensosis (RAS) continues to be a problem for clinicians, with no clear consensus on how to investigate and assess the clinical significance of stenotic lesions and manage the findings.
Thomas M. MacDonald, John G. Houston, Jennings, Claudine G., Bell, Samira; id_orcid, Alison Severn, Isla S. Mackenzie, Mackenzie, Isla S.; id_orcid, MacDonald, Thomas M., Severn, Alison, Samira Bell, Claudine G. Jennings, Houston, John G.   +11 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Have Newer Cardiovascular Drugs Reduced Hospitalization? Evidence From Longitudinal Country-Level Data on 20 OECD Countries, 1995-2003 [PDF]

This study examines the effect of changes in the vintage distribution of cardiovascular system drugs on hospitalization and mortality due to cardiovascular disease using longitudinal country-level data. The vintage of a drug is the first year in which it
Frank R. Lichtenberg
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