Results 1 to 10 of about 9,491,507 (312)

Association of age at first sexual intercourse and lifetime number of sexual partners with cardiovascular diseases: a bi-directional Mendelian randomization study

Frontiers in Cardiovascular Medicine, 2023
BackgroundLimited studies have explored the association between sexual factors [age at first sexual intercourse (AFS) and lifetime number of sexual partners (LNSP)] and cardiovascular diseases (CVDs), leaving the causality inconclusive.MethodsWe ...
Chengui Zhuo, Lei Chen, Qiqi Wang, Haipeng Cai, Zujin Lin, Huili Pan, Meicui Wu, Yuxiang Jin, Hong Jin, Liangrong Zheng   +9 more
doaj   +1 more source

MARS: leveraging allelic heterogeneity to increase power of association testing

Genome Biology, 2021
In standard genome-wide association studies (GWAS), the standard association test is underpowered to detect associations between loci with multiple causal variants with small effect sizes.
Farhad Hormozdiari, Junghyun Jung, Eleazar Eskin, Jong Wha J. Joo   +3 more
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No Causal Association Between Coffee Consumption and Risk of Migraine: A Mendelian Randomization Study

Frontiers in Genetics, 2022
Background and Aims: Coffee consumption has been suggested to increase the risk of migraine. However, causality remains inconclusive. In the present study, we performed a two-sample Mendelian randomization (MR) analysis to investigate the causal ...
Heng Chen, Han Zhang, Liangrong Zheng
doaj   +1 more source

Causal Effect of Obstructive Sleep Apnea on Atrial Fibrillation: A Mendelian Randomization Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Obstructive sleep apnea (OSA) has shown to be associated with an increased risk of atrial fibrillation in observational studies. Whether this association reflect causal effect is still unclear.
Weiqi Chen, Xueli Cai, Hongyi Yan, Yuesong Pan   +3 more
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Self-Reported Walking Pace and Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Frontiers in Genetics, 2022
Background: In observational studies, the self-reported walking pace has been associated with the risk of cardiovascular diseases (CVD). However, whether those associations indicate causal links remains unclear.
Lu Chen, Xingang Sun, Yuxian He, Liangrong Zheng   +3 more
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Causal relationship between ischemic stroke and its subtypes and frozen shoulder: a two-sample Mendelian randomization analysis

Frontiers in Neurology, 2023
BackgroundPrevious epidemiological and other studies have shown an association between ischemic stroke (IS) and frozen shoulder (FS). However, the causal relationship between them remains unclear.
Xiaofeng Lv, Xiaofeng Lv, Zeng Hu, Fangqi Liang, Shanshan Liu, Haiping Gong, Jihang Du, Jihang Du, Xinmin Deng, Jun-Hui Qian, Jun-Hui Qian, Qian Nie, Jian Luo   +12 more
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Increased selenium and decreased iron levels in relation to risk of coronary artery disease in patients with diabetes

Frontiers in Nutrition, 2023
BackgroundObservational studies have reported inconsistent associations between micronutrient levels and the risk of coronary artery disease (CAD) in diabetic patients. We aim to explore the causal association between genetically predicted concentrations
Mengyun Tian, Teng Hu, Teng Hu, Jiajun Ying, Jiajun Ying, Hanbin Cui, Hanbin Cui, Hanbin Cui, Ning Huangfu, Ning Huangfu, Ning Huangfu   +10 more
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Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis

Frontiers in Public Health, 2023
IntroductionOver the past few years, multiple observational studies have speculated a potential association between inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), and osteoporosis. However, no consensus
Zhujiang Dai, Zhujiang Dai, Weimin Xu, Weimin Xu, Rui Ding, Rui Ding, Xiang Peng, Xiang Peng, Xia Shen, Xia Shen, Jinglue Song, Jinglue Song, Peng Du, Peng Du, Zhongchuan Wang, Zhongchuan Wang, Yun Liu, Yun Liu   +17 more
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Protective Effects of Circulating TIMP3 on Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study

Journal of Cardiovascular Development and Disease, 2022
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a protease with high expression levels in the heart and plays an essential role in extracellular matrix turnover by maintaining equilibrium with matrix metalloproteinases.
Heng Chen, Siyuan Chen, Hengni Ye, Xiaogang Guo   +3 more
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Incorporating Covariates into Measures of Surrogate Paradox Risk

Stats, 2023
Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint.
Fatema Shafie Khorassani, Jeremy M. G. Taylor, Niko Kaciroti, Michael R. Elliott   +3 more
doaj   +1 more source