Results 101 to 110 of about 5,850,068 (304)

Prevalence of airflow limitation in outpatients with cardiovascular diseases in Japan [PDF]

, 2014
Katsuya Onishi,1 Daisuke Yoshimoto,2 Gerry W Hagan,3 Paul W Jones4 1Onishi Heart Clinic, Mie, 2Medical Affairs Respiratory, GlaxoSmithKline KK, Tokyo, Japan; 3Independent Consultant, Marbella, Spain; 4Division of Clinical Science, St George's ...
Jones PW, Hagan, GW, Hagan GW, Onishi, K, Jones, PW, Onishi K, Yoshimoto D, Yoshimoto, D   +7 more
core   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Cost-effectiveness of a fixed-dose combination pill for secondary prevention of cardiovascular disease in China, India, Mexico, Nigeria, and South Africa: a modelling study

The Lancet Global Health, 2019
Summary: Background: Fewer than 25% of patients with atherosclerotic cardiovascular disease in countries of low and middle income (LMICs) use guideline-directed drugs for secondary prevention.
John K Lin, MD, Andrew E Moran, MD, Kirsten Bibbins-Domingo, MD, Bode Falase, FRCS, Andrea Pedroza Tobias, MSC, Charuta N Mandke, DOMS, Dhruv S Kazi, MD   +6 more
doaj   +1 more source

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

Advanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong, Chi Cong Nguyen, Hannah Thuy Truong, Kefan Zhu, Adrienne Ji, James Davies, Emanuele Nicotra, Bibhu Sharma, Jingjing Wan, Patrick Pruscino, Shing Wai Wong, Hoang‐Phuong Phan, Phuoc Thien Phan, Nigel H. Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Common carotid intima media thickness and ankle-brachial pressure index correlate with local but not global atheroma burden:a cross sectional study using whole body magnetic resonance angiography [PDF]

, 2014
Common carotid intima media thickness (CIMT) and ankle brachial pressure index (ABPI) are used as surrogate marker of atherosclerosis, and have been shown to correlate with arterial stiffness, however their correlation with global atherosclerotic burden ...
Belch, Jill J. F.; id_orcid, Belch, Jill J F, Faisel Khan, Stephen J Gandy, Gardner, Michael, Weir-McCall, Jonathan R., Rauchhaus, Petra, Adamson, Carly L., Gandy, Stephen J., Gandy Stephen J., Morris, Andrew D., Rauchhaus Petra, Houston, J. Graeme, Allan D Struthers, Lambert, Matthew A., Matthew A Lambert, J Graeme Houston, Ramkumar Prasad Guntur, Struthers Allan D., Lambert Matthew A., Gardner Michael, Adamson Carly L., Jill J F Belch, Michael Gardner, Khan, Faisel; id_orcid, Petra Rauchhaus, Weir-McCall Jonathan R., Jonathan R Weir-McCall, Khan Faisel, Ramkumar, Prasad Guntur, Khan, Faisel, Belch Jill J. F., Morris Andrew D., Carly L Adamson, Struthers, Allan D., Houston J. Graeme, Andrew D Morris, Prasad Guntur Ramkumar   +37 more
core   +2 more sources

Potential Cardiovascular Events Avoided with Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared with Ezetimibe Alone in Patients with Atherosclerotic Cardiovascular Disease Taking Maximally Tolerated Statins

, 2022
BACKGROUND: Patients with atherosclerotic cardiovascular disease who require additional low-density lipoprotein cholesterol (LDL-C) lowering despite maximally tolerated statins have a significant unmet medical need and are at increased risk of future ...
Sasiela, William J., Sasiela, William J, Nash, Beth, Baum, Seth J., Bilitou, Aikaterini, McQueen, R. Brett, Gillard, Kristin K., Baum, Seth J, Ray, Kausik K, Louie, Michael J., Louie, Michael J, Shah, Hemal, Gillard, Kristin K, McQueen, R Brett, Ray, Kausik K.   +14 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

C-peptide: A predictor of cardiovascular mortality in subjects with established atherosclerotic disease [PDF]

, 2017
Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. Levels of C-peptide are increased in these patients and its role in the atherosclerosis progression was studied in vitro and in vivo over the past years.
Stefano Rizza, Ottavia Porzio, Valeria Guglielmi, Guglielmi, Valeria, Cardellini, M, Marina Cardellini, Morelli, M, Pecchioli, C, Guglielmi, V, Cardolini, Iris, Menghini, Rossella, Monica Morelli, Federici, Massimo, Ballanti, M, Rizza, S, Davato, F, Federici, M, Giulia Grappasonni, Ippoliti, A, Iris Cardolini, Chiara Pecchioli, Porzio, O, Davato, Francesca, Porzio, Ottavia, FARCOMENI, Alessio, Rizza, Stefano, Grappasonni, G, Menghini, R, Rossella Menghini, Cardellini, Marina, Ballanti, Marta, Francesca Davato, Alessio Farcomeni, Farcomeni, A, Grappasonni, Giulia, Morelli, Monica, Massimo Federici, Ippoliti, Arnaldo, Marta Ballanti, Cardolini, I, Arnaldo Ippoliti, Pecchioli, Chiara   +41 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source