Results 81 to 90 of about 185,884 (310)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

Nature Communications
The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated.
Sang‑Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee   +13 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Cigarette Smoking and Atherosclerotic Cardiovascular Disease

Journal of Atherosclerosis and Thrombosis
The detrimental effects of cigarette smoking on cardiovascular health, particularly atherosclerosis and thrombosis, are well established, and more detailed mechanisms continue to emerge. As the fundamental pathophysiology of the adverse effects of smoking, endothelial dysfunction, inflammation, and thrombosis are considered to be particularly important.
Ishida, Mari, Sakai, Chiemi, Kobayashi, Yusuke, Ishida, Takafumi   +3 more
openaire   +2 more sources

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

The synergistic effect of the atherogenic index of plasma and hyperuricemia on the prediction of coronary chronic total occlusion lesion: an observational cross-sectional study

Frontiers in Cardiovascular Medicine
BackgroundThe atherogenic index of plasma (AIP) and hyperuricemia (HUA) have been shown to be closely associated with morbidity and mortality of coronary artery disease.
HongYa Han, XiaoLi Liu, Qi Zhao, ZhiJian Wang, Yan Sun, Xiaoteng Ma, MengChen Li, HanYing Ma, YuYang Liu, DongMei Shi, YuJing Cheng, YuJie Zhou   +11 more
doaj   +1 more source

Novel Self‐Report Tool for Cardiovascular Risk Assessment

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The currently used atherosclerotic cardiovascular disease risk calculator relies on several measured variables and does not incorporate some well‐established risk factors such as family history of premature myocardial infarction and other ...
Hend Mansoor, Ara Jo, V. Madsen Beau De Rochars, Carl J. Pepine, Arch G. Mainous   +4 more
doaj   +1 more source

Predicted Versus Observed Major Adverse Cardiac Event Risk in Women With Evidence of Ischemia and No Obstructive Coronary Artery Disease: A Report From WISE (Women's Ischemia Syndrome Evaluation)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Primary prevention risk scores are commonly used to predict cardiovascular (CVD) outcomes. The applicability of these scores in patients with evidence of myocardial ischemia but no obstructive coronary artery disease is unclear.
Tara Sedlak, Romana Herscovici, Galen Cook‐Wiens, Eileen Handberg, Janet Wei, Chrisandra Shufelt, Vera Bittner, Steven E. Reis, Nathaniel Reichek, Carl Pepine, C. Noel Bairey Merz   +10 more
doaj   +1 more source