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Evaluation of Coronary Atherosclerotic Plaques
Cardiology Clinics, 2009In many patients, unheralded myocardial infarction associated with a mortality of approximately 20% is the first manifestation of coronary artery disease. Approximately 40% of the population is considered to have a moderate midterm risk of 10% to 20%. Any of the stratification schemes suffers from a lack of accuracy to correctly determine the risk, and
Christoph R, Becker, Tobias, Saam
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Clonal nature of atherosclerotic plaques
Experimental and Molecular Pathology, 1988The clonal nature of atherosclerotic plaques has been examined in diet-induced atherosclerosis of interspecies hybrid hare females (Lepus timidus (female) X Lepus europaeus (male], which exhibit genetic mosaicism with respect to glucose-6-phosphate dehydrogenase (G6P-D).
C D, Murray +3 more
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Taking AIM2 at atherosclerotic plaques
Nature Reviews Drug Discovery, 2021Clonal haematopoiesis — an expansion of blood cell clones due to advantageous somatic mutations — is linked to myocardial infarction. A new study shows that activation of the AIM2 inflammasome in clonally expanded macrophages exacerbates atherosclerosis by driving both proliferation and pyroptosis.
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Puerto Rico health sciences journal, 2008
Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes interact influencing its ...
J A, Mundo-Sagardía +5 more
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Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes interact influencing its ...
J A, Mundo-Sagardía +5 more
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Hyperspectral characterization of atherosclerotic plaques
SPIE Proceedings, 2009Imaging modalities like hyperspectral imaging create large amounts of data. Time efficient, automated analytic techniques are therefore required to enjoy the power of such methods. In this study it was investigated if hyperspectral imaging followed by automated noise filtering and statistical image analysis is a suitable method for characterization of ...
Lise L. Randeberg +4 more
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Atherosclerotic plaque assessment by NMR
Magnetic Resonance Materials in Physics, Biology and Medicine, 1998Developing imaging technologies capable of identifying unstable atheromatous plaques in vivo is a major issue of clinical cardiovascular research. These techniques would allow an earlier surgical or medical therapy before acute ischemic syndromes [1]. Plaque stability and its counterpart i.e.
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Identification of vulnerable atherosclerotic plaques
Expert Review of Cardiovascular Therapy, 2003There has been great interest in the possibility of identifying plaques that might be the site of future acute coronary events. These plaques are termed vulnerable and the majority are lipid-rich with an abundance of inflammatory cells and a thin fibrous cap.
Cezar S, Staniloae, John A, Ambrose
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Life and death in the atherosclerotic plaque
Current Opinion in Lipidology, 2010Changes in cell mass in atherosclerosis represent changes in cell division, cell death and migration/emigration, all of which may be occurring simultaneously in different cell types at different times and in different regions of the plaque. This makes measurement of these individual processes and measurement of overall cell kinetics in atherosclerosis ...
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The vulnerable and unstable atherosclerotic plaque
Cardiovascular Pathology, 2010The lesion responsible for the overwhelming majority of acute coronary events is plaque disruption or erosion with superimposed thrombosis. The term "vulnerable plaque" has been used to describe those atherosclerotic plaques that are particularly susceptible to disruption.
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Analysis of atherosclerotic plaque distribution in the carotid artery
Clinical Cardiology, 2022Dong-Ik Kim +2 more
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