Results 211 to 220 of about 78,816 (306)

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Gelatinase and Vulnerability of Atherosclerotic Plaque

Journal of Atherosclerosis and Thrombosis, 2016
openaire   +3 more sources

Rationale and Design of the PASSIVATE-CAP Trial: The Preventive Intervention Value of Drug-Coated Balloons in Vulnerable Coronary Atherosclerotic Plaques. [PDF]

Clin Cardiol
Chen Z, Zhang J, Zhou M, Liang S, Chen Y, Li C, Wang H, Wei J, Huang B, Wang M, He Y, PASSIVATE‐CAP trial investigator.   +11 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Intelligent detection method for carotid atherosclerotic plaques based on ultrasound imaging. [PDF]

Brain Circ
Zhu S, Guo L, Qiu X, Jiang M, He C, Sun B, Xu J, Chen G, Ma J, He M, Ji X.   +10 more
europepmc   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries. [PDF]

JVS Vasc Sci
Massie PL, Garcia MA, Gallego D, Schlosser C, Decker A, Liu R, MazloumiBakhshayesh M, Kulkarni D, Justus MP, Pace C, Rumma RT, Campen MJ, Clark RM.   +12 more
europepmc   +1 more source

Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment

The FEBS Journal, EarlyView.
MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley   +1 more source

Multimodal landscape of atherosclerotic plaques: A spatial omics approach with mass spectrometry imaging. [PDF]

Anal Chim Acta
Joshi R, Tang SY, Das US, Boehmler DJ, Mrčela A, Lordan R, Petersson EJ, Weljie AM, FitzGerald GA.   +8 more
europepmc   +1 more source