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Impact of Statins on Atherosclerotic Plaque
Future Cardiology, 2007Lowering levels of low-density lipoprotein cholesterol with inhibitors of 3-hydroxy-methylglutaryl coenzyme A reductase (statins) has a profound impact on cardiovascular event rates. The degree of benefit is proportional to the extent of low-density lipoprotein cholesterol lowering achieved. In addition to lowering levels of atherogenic lipids, statins
Stephen J, Nicholls +2 more
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Evaluation of Coronary Atherosclerotic Plaques
Cardiology Clinics, 2009In many patients, unheralded myocardial infarction associated with a mortality of approximately 20% is the first manifestation of coronary artery disease. Approximately 40% of the population is considered to have a moderate midterm risk of 10% to 20%. Any of the stratification schemes suffers from a lack of accuracy to correctly determine the risk, and
Christoph R, Becker, Tobias, Saam
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Puerto Rico health sciences journal, 2008
Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes interact influencing its ...
J A, Mundo-Sagardía +5 more
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Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes interact influencing its ...
J A, Mundo-Sagardía +5 more
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Agents that stabilise atherosclerotic plaque
Expert Opinion on Investigational Drugs, 2003The concept of plaque stabilisation was developed to explain how medications could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. With this concept, a comprehensive view of atherosclerosis is now appreciated.
Jun R, Chiong, Alan B, Miller
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Progression and regression of the atherosclerotic plaque
European Heart Journal, 1995In animals in which atherosclerosis was induced experimentally (by a high cholesterol diet) regression of the atherosclerotic lesion was demonstrated after serum cholesterol was reduced by cholesterol- lowering drugs or a low-fat diet. Whether regression of advanced coronary arterly lesions also takes place in humans after a similar intervention ...
P J, de Feyter, J, Vos, J W, Deckers
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The vulnerable and unstable atherosclerotic plaque
Cardiovascular Pathology, 2010The lesion responsible for the overwhelming majority of acute coronary events is plaque disruption or erosion with superimposed thrombosis. The term "vulnerable plaque" has been used to describe those atherosclerotic plaques that are particularly susceptible to disruption.
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Cell death in atherosclerotic plaques
Current Opinion in Lipidology, 1996The investigation of the mechanisms of cell death in atherosclerosis has recently received added impetus with the realization that apoptosis is probably the predominant mechanism. This review examines the preliminary data on mechanisms of cell death in the atherosclerotic plaque.
M J, Mitchinson +2 more
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Life and death in the atherosclerotic plaque
Current Opinion in Lipidology, 2010Changes in cell mass in atherosclerosis represent changes in cell division, cell death and migration/emigration, all of which may be occurring simultaneously in different cell types at different times and in different regions of the plaque. This makes measurement of these individual processes and measurement of overall cell kinetics in atherosclerosis ...
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Atherosclerotic plaque assessment by NMR
Magnetic Resonance Materials in Physics, Biology and Medicine, 1998Developing imaging technologies capable of identifying unstable atheromatous plaques in vivo is a major issue of clinical cardiovascular research. These techniques would allow an earlier surgical or medical therapy before acute ischemic syndromes [1]. Plaque stability and its counterpart i.e.
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Atherosclerotic plaque stabilization and regression
VasaSummary: Atherosclerotic plaques represent a typical deterioration of arterial wall in atherosclerotic process and are the source of cardiovascular events. Plaque progression and composition represent a major risk for cardiovascular events. Therefore, recently many studies have assessed changes in plaque characteristics and their response to various ...
Pavel Poredoš +2 more
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