Results 21 to 30 of about 118,937 (337)

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]

, 2017
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl, Ballabio, Andrea, Bhattacharya, Somashubhra, Crowley, Jan R, Dehestani, Babak, Diwan, Abhinav, Epelman, Slava, Evans, Trent D, Fan, Daping, Holloway, Karyn B, Javaheri, Ali, Micevych, Paul S, Razani, Babak, Schilling, Joel D, Sergin, Ismail, Song, Eric, Stokes, Carl J, Weihl, Conrad C, Zayed, Mohamed A, Zhang, Xiangyu   +19 more
core   +2 more sources

The Function, Regulation and Mechanism of Programmed Cell Death of Macrophages in Atherosclerosis

Frontiers in Cell and Developmental Biology, 2022
Atherosclerosis is a chronic progressive inflammatory vascular disease, which is an important pathological basis for inducing a variety of cardio-cerebrovascular diseases. As a kind of inflammatory cells, macrophages are the most abundant immune cells in
Chang Liu, Zecheng Jiang, Zhongjie Pan, Liang Yang   +3 more
doaj   +1 more source

The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis [PDF]

, 2011
Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial ...
Antunes, RF, Dumitriu, IE, Kaski, JC
core   +3 more sources

Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]

, 2020
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy, Bridoux, Jessica, Broisat, Alexis, Caveliers, Vicky, Cleeren, Frederik, Debie, Pieterjan, Descamps, Benedicte, Devoogdt, Nick, Hernot, Sophie, Neyt, Sara, Vanhove, Christian, Xavier, Catarina   +11 more
core   +2 more sources

Research Progress on the Risk Factors and Outcomes of Human Carotid Atherosclerotic Plaques

Chinese Medical Journal, 2017
Objective: Atherosclerosis is an inflammatory process that results in complex lesions or plaques that protrude into the arterial lumen. Carotid atherosclerotic plaque rupture, with distal atheromatous debris embolization, causes cerebrovascular events ...
Xiang-Dong Xiong, Wei-Dong Xiong, Shang-Shen Xiong, Gui-Hai Chen   +3 more
doaj   +1 more source

Relationship between subclasses low-density lipoprotein and carotid plaque

Translational Neuroscience, 2022
Low-density lipoprotein (LDL) cholesterol can lead to the occurrence of atherosclerotic plaques, but patients with normal LDL still have atherosclerotic plaques in clinical practice.
Pan Zhanhai, Guo Huiwen, Wang Qingqing, Tian Sha, Zhang Xiaoxuan, Li Chengbo, Ma Zheng   +6 more
doaj   +1 more source

Understanding the Clinical Implications of Intracranial Arterial Calcification Using Brain CT and Vessel Wall Imaging

Frontiers in Neurology, 2021
Background and Purpose: Intracranial arterial calcification (IAC) has been the focus of much attention by clinicians and researchers as an indicator of intracranial atherosclerosis, but correlations of IAC patterns (intimal or medial) with the presence ...
Wen-Jie Yang, Bruce A. Wasserman, Lu Zheng, Zhong-Qing Huang, Zhong-Qing Huang, Jia Li, Jill Abrigo, Simon Sin-man Wong, Michael Tin-cheung Ying, Winnie Chiu-Wing Chu, Lawrence Ka-sing Wong, Thomas Wai-Hong Leung, Xiang-Yan Chen   +12 more
doaj   +1 more source

Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3 [PDF]

, 2017
In previous work we reported that ApoeKO mice transplanted with bone marrow cells deficient in the Transient Receptor Potential Canonical 3 (TRPC3) channel have reduced necrosis and number of apoptotic macrophages in advanced atherosclerotic plaques ...
Birnbaumer, Lutz, Dube, Prabhatchandra R., Solanki, Sumeet, Vazquez, Guillermo   +3 more
core   +1 more source

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

Exploration of the atherosclerotic plaque

Biomedicine & Pharmacotherapy, 1990
During the past 3 decades we have achieved a better understanding of the atherosclerotic process. It has been described as a series of changes in the intima of arteries consisting of the focal accumulation of lipids, complex carbohydrates, blood and blood products, fibrous tissues, and calcium that are also associated with changes in the media.
John H. Ip, V Fuster, JH Chesebro
openaire   +3 more sources