Results 71 to 80 of about 118,937 (337)

Noninvasive platelet membrane‐coated Fe3O4 nanoparticles identify vulnerable atherosclerotic plaques

Smart Medicine
Vulnerable atherosclerotic plaques serve as the primary pathological basis for fatal cardiovascular and cerebrovascular diseases. The precise identification and treatment of these vulnerable plaques hold paramount clinical importance in mitigating the ...
Yuyu Li, Yujie Wang, Zequn Xia, Yangjing Xie, Daozheng Ke, Bing Song, Dan Mu, Ronghui Yu, Jun Xie   +8 more
doaj   +1 more source

Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]

, 2011
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne, Rutsch, Frank, Terkeltaub, Robert, Weissen-Plenz, Gabriele   +3 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Plasma Testosterone Levels and Atherosclerotic Plaque Gene Expression in Men With Advanced Atherosclerosis

Frontiers in Cardiovascular Medicine, 2021
Aims: Low plasma testosterone levels have been shown to predict worse outcome in men with severe atherosclerotic disease. We hypothesized that a low plasma testosterone level affects disease risk through changes in gene expression in atherosclerotic ...
Floor Groepenhoff, Floor Groepenhoff, Ernest Diez Benavente, Arjan Boltjes, Nathalie Timmerman, Farahnaz Waissi, Robin J. G. Hartman, N. C. Onland-Moret, Gerard Pasterkamp, Hester Den Ruijter   +9 more
doaj   +1 more source

Nicotine strongly activates dendritic cell-mediated adaptive immunity - potential role for progression of atherosclerotic lesions [PDF]

, 2003
Background - Antigen-presenting cells (APCs) such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation in the course of adaptive immunity.
Aicher, A, Cooke, JP, Dimmeler, S, Heeschen, C, Mohaupt, M, Zeiher, AM   +5 more
core   +1 more source

Macrophage heterogeneity in atherosclerotic plaques [PDF]

Current Opinion in Lipidology, 2009
The varied behaviour of macrophages and foam cells during atherosclerosis and its clinical sequelae prompt the question whether all these activities can be the property of a single cell population.Subsets of monocytes with distinct patterns of surface markers and behaviours during inflammation have recently been characterized and shown to have ...
Johnson, JL, Newby, AC
openaire   +4 more sources

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study. [PDF]

, 2016
BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 ...
Bahrami, Hossein, Budoff, Matthew, Haberlen, Sabina A, Ketlogetswe, Kerunne, Kingsley, Lawrence, McConnell, Michael V, Palella, Frank, Post, Wendy S, Rezaeian, Pantea, Tracy, Russell, Witt, Mallory D   +10 more
core   +2 more sources

Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model

Advanced Healthcare Materials, EarlyView.
A modular, triple‐action titanium implant is developed to prevent implant‐associated infections by repelling bacteria, killing pathogens, and enhancing tissue integration. Coatings with phage cocktails targeting P. aeruginosa and S. aureus show significant bacterial reduction and improved survival in a mouse sepsis model.
Martin Stark, Fereshteh Bayat, Sara Rahmani, Mathura Thirugnanasampanthar, Taylor Kramer, Elise Schwarz, David Wilson, Jeffrey I. Weitz, Zeinab Hosseinidoust, Tohid F. Didar   +9 more
wiley   +1 more source

Is it possible to estimate cerebro–vascular risk on the basis of the composition of carotid atherosclerotic plaques?

Zdravniški Vestnik, 2012
Different models for the prediction of cardiovascular and cerebro-vascular events are used, based on the presence of risk factors. This is a statistical risk-assessment model.
Pavel Poredoš, Mateja Kaja Ježovnik, Anže Gošte   +2 more
doaj