Results 61 to 70 of about 78,816 (306)

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

B Lymphocytes and Macrophages in the Perivascular Adipose Tissue Are Associated With Coronary Atherosclerosis: An Autopsy Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Macrophages and T lymphocytes in the perivascular adipose tissue (PvAT) were previously linked to coronary artery disease. However, the role of these cells and B lymphocytes in the human PvAT adjacent to unstable atherosclerotic plaques has ...
Daniela Souza Farias‐Itao, Carlos Augusto Pasqualucci, Aline Nishizawa, Luiz Fernando Ferraz da Silva, Fernanda Marinho Campos, Márcio Sommer Bittencourt, Karen Cristina Souza da Silva, Renata Elaine Paraízo Leite, Lea Tenenholz Grinberg, Renata Eloah de Lucena Ferretti‐Rebustini, Wilson Jacob‐Filho, Claudia Kimie Suemoto   +11 more
doaj   +1 more source

Mechanisms of erosion of atherosclerotic plaques [PDF]

Current Opinion in Lipidology, 2017
Purpose of review The present review explores the mechanisms of superficial intimal erosion, a common cause of thrombotic complications of atherosclerosis. Recent findings Human coronary artery atheroma that give rise to thrombosis because of erosion differ diametrically from those ...
Thibaut, Quillard, Grégory, Franck, Thomas, Mawson, Eduardo, Folco, Peter, Libby   +4 more
openaire   +2 more sources

Ex vivo evaluation of coronary atherosclerotic plaques: characterization with dual-source CT in comparison with histopathology

, 2010
BACKGROUND: Identification and differentiation of coronary atherosclerotic plaques may improve risk stratification for incident coronary events. OBJECTIVE: We investigated the ability of dual-source computed tomography (CT) to depict and characterize ...
Marincek, Borut, Dettmer, M, Goetti, R, Simon Wildermuth, Wunnicke, K, Feuchtner, G, Matthias Dettmer, Leschka, S, Seitun, Sara, Dettmer, Matthias, Borut Marincek, Baumüller, S, Stolzmann, Paul, Wolfram Jochum, Jochum, W, Scheffel, Hans, Gudrun Feuchtner, Goetti, Robert, Kathrin Wunnicke, Marincek, B, Stephan Baumüller, Wildermuth, S, Alkadhi, H, Stolzmann, P, Alkadhi, Hatem, Seitun, S, Leschka, Sebastian, Wildermuth, Simon, Oehlschlegel, Christian, Wunnicke, Kathrin, Paul Stolzmann, Feuchtner, Gudrun, Robert Goetti, Hans Scheffel, Baumüller, Stephan, Oehlschlegel, C, Sara Seitun, Christian Oehlschlegel, Hatem Alkadhi, Scheffel, H, Jochum, Wolfram, Sebastian Leschka   +41 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Is it possible to estimate cerebro–vascular risk on the basis of the composition of carotid atherosclerotic plaques?

Zdravniški Vestnik, 2012
Different models for the prediction of cardiovascular and cerebro-vascular events are used, based on the presence of risk factors. This is a statistical risk-assessment model.
Pavel Poredoš, Mateja Kaja Ježovnik, Anže Gošte   +2 more
doaj  

Identification of potential clinical indicators of carotid plaque disruption using patient specific finite element modelling [PDF]

, 2011
It has been hypothesised that the stress distribution within the arterial wall may provide an indicator of atherosclerotic plaque disruption.
Creane, Arthur
core  

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Mechanical Assessment in Atherosclerosis Based on Photoacoustic Viscoelasticity Imaging

Photonics
Early identification of vulnerable plaques is a major challenge in diagnosis and assessment of atherosclerosis. In atherosclerotic plaque development, the proportion change in components caused plaque mechanical property change and induced plaque rupture.
Xingchao Zhang, Xiaohan Shi, Hui Wu, Caixun Bai, Junshan Xiu, Yue Zhao   +5 more
doaj   +1 more source

Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques. [PDF]

PLoS ONE, 2014
Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (
Bert Rutten, Claudia Tersteeg, Joyce E P Vrijenhoek, Thijs C van Holten, Ellen H A M Elsenberg, Elske M Mak-Nienhuis, Gert Jan de Borst, J Wouter Jukema, Nico H J Pijls, Johannes Waltenberger, Anton Jan van Zonneveld, Frans L Moll, Elizabeth McClellan, Andrew Stubbs, Gerard Pasterkamp, Imo Hoefer, Philip G de Groot, Mark Roest   +17 more
doaj   +1 more source