Results 71 to 80 of about 78,816 (306)

Treating cardiovascular atherosclerotic plaques with Tongmaijiangzhi (tmjz) capsule

, 2013
Atherosclerotic plaques can cause serious syndromes and mortality.  Cholesterol accumulation in the plaques can disrupt the arterial flow, with lumen narrowing and stenosis, which contributes to heart attack and sudden cardiac death.
Wang, Z, Li, Li, Zhang, ZS, Wang, Li, Li, L, Zhao, Li, Zhang, Zhong Shuang, Zhai, ZH, Zhao, L, Zhai, Zhi Hong, Duan, Jun Cang, Wang, L, Qu, DT, Ren, H, Huang, H, Huang, Hui, Duan, JC, Wang, Zhong, Qu, De Tao, Ren, Hong-Qiang   +19 more
core   +1 more source

Dating Components of Human Atherosclerotic Plaques [PDF]

, 2010
Rationale: Atherosclerotic plaques that give rise to acute clinical symptoms are typically characterized by degradation of the connective tissue and plaque rupture.
Stenström, Kristina, Nilsson, Jan, Goncalves, Isabel, Skog, Göran, Nitulescu, Mihaela, Mattsson, Sören   +5 more
core   +1 more source

Ultraselective Carbon Nanotubes for Photoacoustic Imaging of Inflamed Atherosclerotic Plaques

, 2021
Disruption of vulnerable atherosclerotic plaques often leads to myocardial infarction and stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method that detects high-risk atherosclerotic plaques at early stages could
Leeper, Nicholas, Devon J. Eddins, Hisanori Kosuge, Larson, Timothy, McConnell, Michael V., Smith, Bryan Ronain, Eliver E. B. Ghosn, Sanjiv Sam Gambhir, Timothy Larson, Kosuge, Hisanori, Yapei Zhang, Paluri, Sesha L. A., Mahsa Gifani, Gifani, Mahsa, Eddins, Devon J., Leonore A. Herzenberg, Michael V. McConnell, Ghosn, Eliver E. B., Nicholas Leeper, Bryan Ronain Smith, Zhang, Yapei, Herzenberg, Leonore A., Sesha L. A. Paluri, Gambhir, Sanjiv Sam   +23 more
core   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Biofabrication and mechanical characterization of hydrogel-based atherosclerotic plaques for the in vitro testing of drug-coated balloons

, 2023
LAUREA MAGISTRALERealistic in vitro models are essential to the evalation and development of new treatments. In this work, a hydrogel-based atherosclerotic plaque was fabricated and mechanically characterized with the purpose to be used in drug-coated ...
FELIÚ PÉREZ, ANDREA MARÍA
core  

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Proteomic analysis of atherosclerotic plaque

Biomedicine & Pharmacotherapy, 2010
Proteins play a fundamental role in the formation and progression of plaque, but proteomic analysis of plaque as a whole is difficult, due to its heterogeneous cellular composition and an abundance of plasma proteins. Several approaches to this problem are reported in the literature; they include proteomic analysis of vascular tissues, analysis of ...
PORCELLI B., CIARI I., FELICI C., PAGANI R., BANFI C., BRIOSCHI M., GIUBBOLINI M., DE DONATO G., SETACCI C., TERZUOLI L.   +9 more
openaire   +5 more sources

Microbial composition of atherosclerotic plaques [PDF]

Oral Diseases, 2014
ObjectiveThe association of infections such as periodontitis with atherosclerotic diseases is well documented. In spite of the high diversity of the human oral microbiota, and its close contact with the circulatory system, few oral species were detected in atherosclerotic plaques.
C A, Calandrini, A C, Ribeiro, A C, Gonnelli, C, Ota-Tsuzuki, L P, Rangel, E, Saba-Chujfi, M P A, Mayer   +6 more
openaire   +2 more sources

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability

Mediators of Inflammation, 2020
Matrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability.
Tiewei Li, Xiaojuan Li, Yichuan Feng, Geng Dong, Yuewu Wang, Junmei Yang   +5 more
doaj   +1 more source