Results 131 to 140 of about 42,048 (220)

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025

Movement Disorders, Volume 41, Issue 9, Page 2267-2277, September 2026.
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova, Jenny Townhill, Juliana Bronzova, Viktoria Andreeva, Swati Sathe, Cristina Sampaio   +5 more
wiley   +1 more source

MSI: A Mahalanobis‐Based Molecular Similarity Index for High‐Dimensional Embeddings

Molecular Informatics, Volume 45, Issue 9, September 2026.
MSI pairs continuous Mol2Vec embeddings with a covariance‐aware Mahalanobis metric (dM, θM) to overcome the ranking ties and bit‐density bias of Tanimoto fingerprints. Across five reference compounds, MSI resolves more distinct neighbors than ECFP4 + Tanimoto and its geometry tracks HOMO–LUMO gaps in QM9, despite no electronic training.
Roberto Bernal‐Jaquez, Elliot Ridout‐Buhl, Emiliano Montoya, León Alday‐Toledo, Felipe Aparicio   +4 more
wiley   +1 more source

Near and distance vergence facility provides complementary clinical information in concussion‐related convergence insufficiency

Optometry and Vision Science, Volume 103, Issue 9, September 2026.
ABSTRACT Purpose To compare near and distance vergence facility testing in adolescents and young adults with concussion‐related convergence insufficiency and evaluate changes following office‐based vergence/accommodative therapy (OBVAM). Methods This secondary analysis of the CONCUSS randomized clinical trial evaluated vergence facility at near (40 cm)
Mitchell Scheiman, Tara L. Alvarez, Farzin Hajebrahimi, Melissa Noble, Matthew L. Robich, Rebecca Baro, Josie A. Bachman, Christina L. Master, Arlene Goodman, the CONCUSS Investigator Group, Katie Rownd, Jordan Wentz, Melissa Crawford, Regina Antoni   +13 more
wiley   +1 more source

Optimizing anatomic site selection for needle decompression and chest tube placement for pneumothorax in pregnancy

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Introduction Tension pneumothorax can cause life‐threatening respiratory and cardiac complications. Prompt decompression is essential, with current guidelines favoring the fourth or fifth intercostal space (ICS) at the anterior axillary line (AAL) over the traditional second ICS at the midclavicular line (MCL).
Beverly Claire Tse, Tonya Tucker, Ava G. Holland, Benjamin Sutton, Caroline Berberian, Poorna Balakumar, Kasey McKenna, Andrea D. Shields   +7 more
wiley   +1 more source

KAT6A–inhibitor co‐crystal structures: tackling a challenging crystallization target via two alternative approaches

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.
We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter, Léa Bouché, Katrin Nowak-Reppel, Steven J. Ferrara, Stefan N. Gradl, Daniel Korr, Craig A. Strathdee, Antonius ter Laak, Roman C. Hillig   +8 more
wiley   +1 more source

Consistent Buzz‐Pollination Posture Suggests Division of Labour Between Dimorphic Stamens in Bredia hirsuta (Melastomataceae) on Okinawa‐Jima Island, Japan

Plant Species Biology, Volume 41, Issue 5, September 2026.
Bredia hirsuta, a small pollen flower, is buzz‐pollinated by Amegilla dulcifera in a posture separating ventral gripping from dorsal stigma contact. The bee grips short‐stamen ventrally, while the stigma contacts the dorsal abdomen near long‐stamen anther tips.
Tetsuya Fukano, Tetsuo Denda
wiley   +1 more source

AI washing

American Business Law Journal, Volume 63, Issue 3, Page 193-233, Fall 2026.
Abstract AI washing, the practice of misrepresenting the use or scope of artificial intelligence in goods or services to attract investors and gain competitive advantages, raises distinct regulatory challenges requiring the adaptation of traditional securities laws to novel technological contexts.
Moran Ofir
wiley   +1 more source

Alantolactone inhibits T-cell lymphoma progression by suppressing CD47 expression via the PI3K/AKT and ERK signaling pathways. [PDF]

Apoptosis
Li X, Pang N, Chen Y, Pan T, Sun W, Chen B, Xie F, Mu Y, Li N.   +8 more
europepmc   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, Volume 183, Issue 17, Page 5389-5406, September 2026.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Frontotemporal dementia with right temporal predominance: a clinical comparison with left-predominant FTD. [PDF]

J Neurol
Thompson JC, Kobylecki C, Jones M, Haigh J, Larbey M, Langheinrich TC, Thomasson R, Richardson AMT, Snowden JS.   +8 more
europepmc   +1 more source