Results 91 to 100 of about 2,169,760 (391)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

IDF diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045.

Diabetes Research and Clinical Practice, 2021
Hong Sun, Pouya Saeedi, S. Karuranga, Moritz Pinkepank, K. Ogurtsova, B. Duncan, C. Stein, A. Basit, J. Chan, J. Mbanya, Meda E. Pavkov, Ambady Ramachandaran, S. Wild, S. James, W. Herman, Ping Zhang, C. Bommer, S. Kuo, E. Boyko, D. Magliano   +19 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Mapping the depleted area of silicon diodes using a micro-focused X-ray beam

, 2018
For the Phase-II Upgrade of the ATLAS detector at CERN, the current ATLAS Inner Detector will be replaced with the ATLAS Inner Tracker. The ATLAS Inner Tracker will be an all-silicon detector, consisting of a pixel tracker and a strip tracker.
Bloch, Ingo, Blue, Andrew, Buttar, Craig, Fadeyev, Vitaliy, Fernandez-Tejero, Javier, Fleta, Celeste, Hacker, Johannes, Llacer, Carlos Lacasta, Miñano, Mercedes, Poley, Luise, Renzmann, Martin, Rossi, Edoardo, Sawyer, Craig, Sperlich, Dennis, Stegler, Martin, Ullán, Miguel, Unno, Yoshinobu   +16 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

ATLAS Forward Detectors and Physics

, 2010
In this communication I describe the ATLAS forward physics program and the detectors, LUCID, ZDC and ALFA that have been designed to meet this experimental challenge.
Soni, N.
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Stony Brook / SMARTS Atlas of mostly Southern Novae

, 2012
We introduce the Stony Brook / SMARTS Atlas of (mostly) Southern Novae. This atlas contains both spectra and photometry obtained since 2003. The data archived in this atlas will facilitate systematic studies of the nova phenomenon and correlative studies
Andrew Battisti, Bode M. F., Bond H. E., Dworetsky M. M., Frederick M. Walter, Guy S. Stringfellow, Howard E. Bond, Hughes J. P., Hung L. W., Liller W., Liller W., McLaughlin D. B., Naik S., Nakano S., Patterson J., Payne-Gaposchkin C., Read A. M., Sarah E. Towers, Seach J., Silviero A., Smak J. I., Starrfield S., Walter F. M.   +22 more
core   +1 more source

Morphology of the transverse ligament of the atlas and the alar ligaments in the silver fox (Vulpes vulpes var) [PDF]

, 2013
Background Recent new anatomical and histological features of craniocervical junction in dogs and cats were described providing evidence of differences between the carnivore species. No information on these structures in foxes exists.
Barszcz, Karolina, Czubaj, Norbert, Janczyk, Pawel, Kupczynska, Marta, Wasowicz, Michal   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source