Results 31 to 40 of about 808,349 (313)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

El teatro de la Universidad de Concepción durante la Unidad Popular (UP) en Chile 1970 -1973. Democracia y política

Anagramas Rumbos y Sentidos de la Comunicación, 2014
La presente investigación centró su preocupación en el teatro de la Universidadde Concepción durante el período de la Unidad Popular (1970 - 1973). Tuvocomo objetivo analizar los imaginarios sociales de la democracia y del arteescénico, presentes en esta
Luis Nitrihual Valdebenito, Jenniffer Lobos Saavedra, Juan Manuel Fierro Bustos, Javier Mayorga Rojel, Oscar Salinas Santelices   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Modelo educativo basado en competencias en universidades politécnicas en México: percepción de su personal docente-administrativo / Based on competencies educational model in polytechnic´s universities in Mexico: the teaching and administrative managing..

Actualidades Investigativas en Educación, 2012
El presente artículo muestra la percepción del profesorado, personal administrativo y directivo sobre el Modelo Educativo Basado en Competencias en las Universidades Politécnicas en México a diez años de su implementación; mediante una recolección de ...
Raymundo Lozano Rosales, Amparo Nidia Castillo Santos, María Trinidad Cerecedo Mercado   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Gemological and Chemical Characterization of Gem-Quality Titanite from Morocco

Crystals
Titanite is a widespread accessory mineral in igneous, metamorphic, and hydrothermal rocks, but few comply with gem-grade requirements. Previous studies on Moroccan titanite focused on elementary composition and U-Pb dating.
Yu Yuan, Zhuang Miao, Yi Zhao, Bo Xu, Jialu Gu, Pengyu Yuan   +5 more
doaj   +1 more source

MODIS Does Not Capture the Spatial Heterogeneity of Snow Cover Induced by Solar Radiation

Frontiers in Earth Science, 2021
Estimating snowmelt in semi-arid mountain ranges is an important but challenging task, due to the large spatial variability of the snow cover and scarcity of field observations. Adding solar radiation as snowmelt predictor within empirical snow models is
Hafsa Bouamri, Christophe Kinnard, Abdelghani Boudhar, Abdelghani Boudhar, Simon Gascoin, Lahoucine Hanich, Lahoucine Hanich, Abdelghani Chehbouni, Abdelghani Chehbouni   +8 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Análisis de la implementación de una Política Pública Educativa utilizando la herramienta Atlas Ti

miradas (Pereira), 2022
Una política pública se genera de la necesidad de modificar una situación problema identificada en una sociedad, por medio de acciones tomadas desde un ente gubernamental (Deubel, 2002) en Colombia en el año 2015 se planteó la Política de Día de la Excelencia como respuesta a la necesidad de mejorar los resultados académicos y alcanzar el objetivo de ...
openaire   +1 more source

ATLAS Feature: Looking inside trillion degree matter

, 2022
Images included in the ATLAS Feature article, "Looking inside trillion degree matter with ...
ATLAS Collaboration
core