Results 41 to 50 of about 808,349 (313)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Islas, 2021 El objetivo del estudio es analizar las representaciones de la violencia como asimetría social y sus mediaciones sociales a partir de los dos personajes femeninos de los filmes María llena eres de gracia e Ixcanul Vulcano. Para ello se empleó el análisis
Maylen Villamañan Alba +1 more
doaj
Revista UNEMAT de Contabilidade, 2022 O objetivo do estudo foi compreender como está constituída a imagem do curso e da profissão contábil perante discentes de ciências contábeis. Por meio dos pressupostos da Teoria das Representações Sociais e dos estereótipos da profissão contábil ...
Jéssica Karine de Oliveira Gomes +2 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Embedded implementation research determinants in Latin American health systems
Revista de Saúde Pública, 2021 OBJECTIVE: To assess the determinants of embedded implementation research (EIR) conduct in seven Latin American and Caribbean countries. METHODS: This qualitative interpretative study conducted and analyzed 14 semi-structured interviews based on a ...
Rodrigo García-Cerde +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Revista Administração em Diálogo, 2015 Empresas capazes de configurar recursos e capacidades, distintivamente, deverão fornecer aos clientes mais valor do que os competidores (TEECE et al., 1997).
Alexandre Rabêlo Rabêlo +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
ATLAS Event Display: photonuclear collision
, 2021 Event display of a photonuclear collision, where a high-energy photon strikes a lead nucleus, recorded by the ATLAS detector during 2018 Pb+Pb collision period.
ATLAS Collaboration
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