Results 111 to 120 of about 2,927,504 (337)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

open access: yesFEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran   +3 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

open access: yesFEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda   +9 more
wiley   +1 more source

Planetary atmosphere albedo [PDF]

open access: yes
Computation of plane and spherical albedo of planetary ...
Sobolev, V. V.
core   +1 more source

Atmospheric Escape by Magnetically Driven Wind from Gaseous Planets II --Effects of Magnetic Diffusion--

open access: yes, 2015
We investigate roles of Alfvenic waves in the weakly-ionized atmosphere of hot Jupiters by carrying out non-ideal magnetohydrodynamic (MHD) simulations with Ohmic diffusion in one-dimensional magnetic flux tubes.
Inutsuka, Shu-ichiro   +2 more
core   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

open access: yesFEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo   +11 more
wiley   +1 more source

Atmospheric Photochemistry [PDF]

open access: yes, 2017
International ...
Lefèvre, Franck, Krasnopolsky, Vladimir
openaire   +3 more sources

Modeling and calculating the albedo and IR heat flux applied to satellite based on the geographic position of sarellite [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2019
In this paper, a precise method for calculating albedo and IR heat flux applied to a satellite is presented. For obtaining albedo heat flux applied to a satellite, a point on the earth’s surface that sun flux reflected at that point and reach to the ...
Behzad Mohasel afshari   +3 more
doaj  

Why one-dimensional models fail in the diagnosis of average spectra from inhomogeneous stellar atmospheres

open access: yes, 2011
We investigate the feasibility of representing a structured multi-dimensional stellar atmosphere with a single one-dimensional average stratification for the purpose of spectral diagnosis of the atmosphere's average spectrum.
Abbett   +32 more
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

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