Results 51 to 60 of about 1,042,967 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Export of ice-nucleating particles from watersheds: results from the Amazon and Tocantins river plumes

Royal Society Open Science, 2023
We examined ice-nucleating particles (INPs) in the plumes of the Tocantins and Amazon rivers, which drain watersheds with different proportions of degraded land.
Annika Einbock, Emma Burtscher, Claudia Frey, Franz Conen   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Oceanic planetary waves in the coupled ocean-atmosphere system [PDF]

, 2005
The propagation of planetary, or Rossby, waves is studied under the effects of different atmospheric couplings. First, analytical matchings are formulated in which a Rossby wave is coupled to different thermodynamical atmospheres, from a simple heat flux
Farneti, R., Farneti, Riccardo
core  

Modeling the signature of sulfur mass-independent fractionation produced in the Archean atmosphere

, 2014
Minor sulfur isotope anomalies indicate the absence of O2 from the Archean atmosphere. A rich dataset showing large variations in magnitude and sign of Δ33S and Δ36S, preserved in both sulfates and sulfides, suggests that further constraints on Archean ...
Claire, Mark, Meadows, Victoria, Domagal-Goldman, Shawn D., Stueken, Eva, Claire, Mark W., Domagal-Goldman, Shawn, Kasting, James F., Stüeken, Eva E., Meadows, Victoria S., Kasting, James, Buick, Roger   +10 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Sublimation of ice particles from rocket exhausts in the upper atmosphere [PDF]

, 2003
The process of sublimation of ice particles from a rocket exhaust in the upper atmosphere is examined. Heating by solar radiation and losses of energy by means thermal radiation and sublimation are taken into account in the thermal balance of the ice ...
Kosch, Mike J., Platov, Y. V.
core  

Diagnosis of Local Land-Atmosphere Feedbacks in India

, 2011
Following the convective triggering potential (CTP)–humidity index (HIlow) framework by Findell and Eltahir, the sensitivity of atmospheric convection to soil moisture conditions is studied for India.
Hutjes, R.W.A., R. W. A. Hutjes, O. A. Tuinenburg, C. M. J. Jacobs, Tuinenburg, O.A., P. Kabat, Jacobs, C.M.J., Kabat, P.   +7 more
core   +1 more source

Pluto’s atmosphere from stellar occultations in 2012 and 2013 [PDF]

, 2015
A. Dias-Oliveira is thankful for the support of the following grants: CAPES (BEX 9110/12-7) FAPERJ/PAPDRJ (E-45/2013). R. Vieira-Martins acknowledges the following grants: CNPq-306885/2013, CAPES/Cofecub-2506/2015, FAPERJ/PAPDRJ-45/2013.
Vanzi, L., Lecacheux, J, Widemann, T, Decock A., Girard J. H., Dumas C., Gomes-Júnior, A.,, Vieira Martins, Roberto, Braga-Ribas, Felipe, Fabrega Polleri, Joaquin, Vanzi, Leonardo, Gil-Hutton R., Ortiz J. L., Fabrega Polleri, J., Roques, Françoise, Lellouch, Emmanuel, Thirouin, A, Lopez-Sisterna, Cecília, Opitom C., Lecacheux J., Colas, F., Lopez-Sisterna, C, Jørgensen, U., Thirouin, Audrey, Jehin, E., Leiva, Rodrigo, Gil-Hutton, Ricardo, Leiva R., Ivarsen, Kevin, Gillon, M, Jehin E., Doressoundiram A., Jorgensen, U, Opitom, C., Ortiz, J. L., Camargo J. I. B., LaCluyze, Aaron, Nagy, Leslie, Ivanov, Valentin, Haislip, Joshua B., Decock, Alice, Gomes-Júnior, A. R., Gomes-Junior, Ar, Braga-Ribas, F., Ivanov, Valentin D., Meza, E, Colas F., Lellouch, E, Vieira-Martins, R, Fabrega Polleri, J, LaCluyze, A. P., Lacluyze A. P., Haislip, J. B., Ivarsen, K. M., Hau G. K. T., Jorgensen U., Skottfelt J., Benedetti-Rossi, G., Pollock, Joe, Gomes-Júnior, Altair, Skottfelt, J, Sicardy, Bruno, Doressoundiram, Alain, Soulier, J., Colas, François, Pollock J., Gil-Hutton, R., François Soulier, Jean, Decock, A., Dias-Oliveira A., Girard, J., Snodgrass, Colin, Maury, A., Gillon, Michaël, Gillon M., Pollock, J, Dias-Oliveira, Alex, Manfroid, Jean, Widemann, Thomas, Nagy, L, Bendetti-Rossi, Gustavo, Thirouin, A., Dumas, C., Ignácio Bueno Camargo, Júlio, Camargo, Jib, Dias-Oliveira, A., Opitom, Cyrielle, Girard, J. H., Sicardy, B, Gillon, M., Lacluyze, Aaron P., Hau, G. K. T., Nagy L., Reichart D. E., Ivarsen K. M., Ivanov, V. D., Manfroid, J., Roques, F., Lecacheux, J., Ortiz, José Luiz, Roques, F, Lellouch E., Jehin, E, Morales, N, Girard, Jh, Soulier, J. F., Leiva, R., Snodgrass, C, Nagy, L., Mancini, Luigi, Assafin, Marcelo, Emilio, M., Meza, Erick, Lopez-Sisterna C., Dumas, C, Opitom, C, Meza E., Colas, F, Maury, A, Assafin M., Snodgrass C., Roques F., Decock, A, Camargo, J. I. B., Sicardy, B., Mancini, L., Skottfelt, J., Vieira-Martins, R., Benedetti-Rossi G., Girard, Julien, Ortiz, Jl, Ivarsen, K., Gil-Hutton, R, Hau, George, Assafin, M, Gomes-Júnior, A., R, Morales N., Skottfelt, Jesper, Camargo, J. I.B., Braga-Ribas F., Lellouch, E., Assafin, M., Reichart, De, Soulier, Jf, Camargo, J., I B, Maury, Alain, Vieira-Martins R., Leiva, R, Reichart, D., Doressoundiram, A, Widemann T., Emilio, M, Meza, E., Lopez-Sisterna, C., Ivarsen, Km, Hau, G., Vieira-Martins, Roberto, Dias-Oliveira, A, Fabrega Polleri J., Doressoundiram, A., Jørgensen, Uffe, Jorgensen, U., Soulier J. F., Ivanov, V., Haislip J. B., Haislip, Jb, Emílio, Marcelo, Pollock, J., Gillon, Michel, Reichart, D. E., Lecacheux, Jean, Morales, Nicolas, Haislip, J., Mancini, L, Camargo, J.,, Vanzi L., Hau, Gkt, Dominik, M., Benedetti-Rossi, G, Lacluyze, A., Emilio M., Dumas, Christophe, Dominik, M, Dominik, Martin, Snodgrass, C., Widemann, T., Thirouin A., Sicardy B., Morales, N., Ivanov V. D., Gomes-Junior A. R., Vanzi, L, Ivanov, Vd, Braga-Ribas, F, Reichart, Daniel, Manfroid J., Lacluyze, Ap, Ivarsen, Kevin M., Jehin, Emmanuel, Pollock, Joseph T., Hau, G. K.T., Manfroid, J, Dominik M., Ortiz, J., Girard, J. H. V., Jørgensen, Uffe G., Maury A.   +206 more
core   +1 more source