Results 61 to 70 of about 1,042,967 (307)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Atmospheric and Fog Effects on Ultra-Wide Band Radar Operating at Extremely High Frequencies

Sensors, 2016
The wide band at extremely high frequencies (EHF) above 30 GHz is applicable for high resolution directive radars, resolving the lack of free frequency bands within the lower part of the electromagnetic spectrum.
Nezah Balal, Gad A. Pinhasi, Yosef Pinhasi   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Ein internes Vorhersagbarkeitsexperiment im Lorenz Modell

Meteorologische Zeitschrift, 1995
Die Vorhersagbarkeit der Atmosphäre wird vielfach durch die klassischen Größen der Fehlerverdopplungszeit und des Vorhersagbarkeitsendes quantifiziert. Diese Maße sind mittlere Zeiten, nach denen kleine Anfangsfehler sich verdoppelt bzw. einen bestimmten
Christine Ziehmann-Schlumbohm, Klaus Fraedrich, Leonard A. Smith   +2 more
doaj   +1 more source

Cuerpo, Atmósfera y Tipología Climática: hacia una Arquitectura de la Vida Cotidiana = Body, Atmosphere, and Climatic Typology: toward an Architecture for Everyday Life

Cuadernos de Proyectos Arquitectónicos, 2020
Resumen A lo largo de las últimas dos décadas, y ante la creciente preocupación por el medio ambiente y el cambio climático, la arquitectura ha explorado las oportunidades abiertas por los campos de la termodinámica y la ecología.
Javier García-Germán
doaj   +1 more source

Energetic particle precipitation into the middle atmosphere triggered by a coronal mass ejection [PDF]

, 2007
Precipitation of relativistic electrons into the atmosphere has been suggested as the primary loss mechanism for radiation belt electrons during large geomagnetic storms.
Mccarthy, M.P., Rodger, C. J., Ulich, T., Kavanagh, A.J., Spanswick, E., Clilverd, M. A., Kokorowski, M., Rodger, C.J., Sample, J.G., Millan, R.M., Sample, J. G., Millan, R. M., McCarthy, M. P., Clilverd, M.A., Raita, T., Kavanagh, Andrew J.   +15 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Atmospherics due to Fronts in the Upper Atmosphere

Journal of geomagnetism and geoelectricity, 1953
For a long time a distinctive tonal distribution of atmospherics has been observed on the Pacific Ocean in lat. 30° to 40°N all the year round especially in autumn and winter. Although they are not so strong as those from southern districts, they are often found even in the interior of Asia at night and have a fairly narrow tonal distribution.Abundant ...
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cloud and rain processes in a biosphere-atmosphere interaction context in the Amazon Region [PDF]

, 2002
This paper presents an overview of the results from the first major mesoscale atmospheric campaign of the Large-Scale Biosphere-Atmosphere Experiment in Amazonia (LBA) Program.
Rocha, H., Andreae, M.O., Silva Dias, M. A. F., E. Zipser, Manzi, A., M. O. Andreae, Garstang, M., Dolman, A.J., Manzi, A.O., Silva Dias, P. L., Fuentes, J., Gielow, R., Rocha, H.R., Nobre, C., C. Nobre, L. Gatti, Alvala, R.C.S., Artaxo, P., R. Gielow, J. D. Fuentes, R .C. S. Alvalá, Sa, L.D.A., Andreae, M. O., Fisch, G., M. Garstang, L. D. A. Sá, Dolman, A.J.; id_orcid, Rutledge, S., A. Plana‐Fattori, Zipser, E., P. Kabat, P. L. Silva Dias, Fuentes, J.D., Manzi, A. O., Silva Dias, M.A.F., G. Fisch, Dolman, A., A. O. Manzi, Sá, L. D. A., Fuentes, J. D., S. Rutledge, Kabat, P., Plana-Fattori, A., Silva Dias, P., Sá, L., Silva Dias, P.L., Andreae, M., Marengo, J., Gatti, L., Rocha, H. R., Dolman, A. J., P. Artaxo, Alvalá, R. C. S., H. R. Rocha, Alvalá, R., M. A. F. Silva Dias, Silva Dias, M., J. Marengo, A. J. Dolman   +58 more
core   +1 more source