Results 61 to 70 of about 1,258,692 (296)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
, 2022 Numerical simulation of the general atmospheric circulation was performed to estimate changes in amplitudes of the westward-travelling planetary waves (PWs) at altitudes from the Earth’s surface up to 300 km under different solar activity (SA ...
Elena N. Savenkova +4 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
, 2023 It has been found in experiments at the SURA mid-latitude heating facility that the modification of the ionospheric F2 layer by powerful HF radio waves gives rise to artificial injection of energetic electrons from the Earth’s radiation belt into ...
Vladimir L. Frolov, Arkady V. Troitsky
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Atmospherics due to Fronts in the Upper Atmosphere
Journal of geomagnetism and geoelectricity, 1953 For a long time a distinctive tonal distribution of atmospherics has been observed on the Pacific Ocean in lat. 30° to 40°N all the year round especially in autumn and winter. Although they are not so strong as those from southern districts, they are often found even in the interior of Asia at night and have a fairly narrow tonal distribution.Abundant ...
openaire +2 more sources
Nuclear Physics B - Proceedings Supplements, 2000 To be published in the proceedings of TAUP99 Conference College de France - Paris 6-10 September 1999 11 pages 12 ...
openaire +2 more sources
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source