Results 71 to 80 of about 1,042,967 (307)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2022 Numerical simulation of the general atmospheric circulation was performed to estimate changes in amplitudes of the westward-travelling planetary waves (PWs) at altitudes from the Earth’s surface up to 300 km under different solar activity (SA ...
Elena N. Savenkova +4 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Review of the Dynamics and Oscillations of the Atmosphere
, 2012 The atmosphere is a complex, dynamic system and the weather depends on its state. There are many different phenomena that affect the state of the atmosphere - some only involve the atmosphere, others involve the interaction between the atmosphere and the
Ross, Joseph
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
THE STUDY OF THE NATURE OF THE DEPENDENCE AGEOSTROPHIC WIND SPEED FROM TIME
Наука. Инновации. Технологии, 2022 This paper examines the nature of the dependence ageostrophic compo-nent of the wind from time to time. The authors made a derivation of the equation, reflecting the dependence of ageostrophic velocity components from time to time.
Robert Gurgenovich Zakinyan +1 more
doaj
Effect of Annealing Atmosphere on the Galvanizing Behaviour of a Dual Phase Steel [PDF]
, 2006 The selective surface oxidation of alloying elements such as Mn can cause dual phase (DP) steel wettability problems by liquid Zn during continuous galvanizing. It is well known that process parameters, such as the annealing atmosphere %H2 and dew point,
Khondker, Rubaiyat
core
, 2023 It has been found in experiments at the SURA mid-latitude heating facility that the modification of the ionospheric F2 layer by powerful HF radio waves gives rise to artificial injection of energetic electrons from the Earth’s radiation belt into ...
Vladimir L. Frolov, Arkady V. Troitsky
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source