Results 61 to 70 of about 482,225 (294)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Subpolar Activation of Halogen Heterogeneous Chemistry in Austral Spring

Geophysical Research Letters, 2021
Heterogeneous halogen chemistry plays a dominant role in driving changes in polar chemical composition and ozone depletion. Activation of halogens outside the polar regions may result in depletion of local ozone, along with changes in the chemical ...
Brian Zambri, Douglas E. Kinnison, Susan Solomon   +2 more
doaj   +1 more source

Nitrogen Incorporation in CH_4-N_2 Photochemical Aerosol Produced by Far Ultraviolet Irradiation [PDF]

, 2012
Nitrile incorporation into Titan aerosol accompanying hydrocarbon chemistry is thought to be driven by extreme UV wavelengths (λ120 nm is presently unaccounted for in atmospheric photochemical models.
Jimenez, Jose L., Tolbert, Margaret A., Toon, Owen B., Trainer, Melissa G., Yung, Yuk L.   +4 more
core  

An overview of atmospheric deposition chemistry over the Alps: present status and long-term trends [PDF]

, 2006
Several research programs monitoring atmospheric deposition have been launched in the Alpine countries in the last few decades. This paper uses data from previous and ongoing projects to: (i) investigate geographical variability in wet deposition ...
Arisci, Sylvia, Balestrini, Raflaella, Barbieri, Alberto, Brizzio, Maria Cristina, Kalina, Michael, Mosello, Rosario, Nickus, Ulrike, Probst, Anne, Puxbaum, Hans, Rogora, Michela, Schmitt, Marcel, Stähli, Manfred, Thimonier, Anne, Ulrich, Erwin, Waldner, Peter   +14 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Global/Regional Integrated Model System‐Chemistry Climate Model: 1. Simulation Characteristics

Earth and Space Science, 2019
This study describes the simulation characteristics of a newly developed Global/Regional Integrated Model system‐Chemistry Climate Model (GRIMs‐CCM), which is listed in Chemistry Climate Model Initiative as a participating model.
Yong‐Cheol Jeong, Sang‐Wook Yeh, Seungun Lee, Rokjin J. Park   +3 more
doaj   +1 more source

Atmospheric chemistry

Eos, Transactions American Geophysical Union, 1971
The current intense concern with environmental quality in the United States has resulted in maintaining or possibly even increasing the amount of research in atmospheric chemistry in a period of scientific retrenchment. Thus there has been increasing emphasis during the last few years on the use of chemistry to determine effects of mankind on the earth'
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Impact of Cometary “Impacts” on the Chemistry, Climate, and Spectra of Hot Jupiter Atmospheres

The Astrophysical Journal
Impacts from icy and rocky bodies have helped shape the composition of Solar System objects; for example, the Earth–Moon system, or the recent impact of comet Shoemaker–Levy 9 with Jupiter.
F. Sainsbury-Martinez, C. Walsh
doaj   +1 more source