Results 51 to 60 of about 97,049 (263)

A Global/Regional Integrated Model System‐Chemistry Climate Model: 1. Simulation Characteristics

Earth and Space Science, 2019
This study describes the simulation characteristics of a newly developed Global/Regional Integrated Model system‐Chemistry Climate Model (GRIMs‐CCM), which is listed in Chemistry Climate Model Initiative as a participating model.
Yong‐Cheol Jeong, Sang‐Wook Yeh, Seungun Lee, Rokjin J. Park   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Multiphase Chemistry in the Atmosphere

CHIMIA
Earth’s atmosphere comprises a complex mix of gas and condensed phases, where condensed phases facilitate multiphase chemical reactions that would not occur in the gas phase alone. These reactions drive dynamic physical and chemical processes across various spatial and temporal scales, playing a crucial role in the cycling of atmospheric trace ...
Ammann, Markus, Alpert, Peter A., Artiglia, Luca, Bao, Fengxia, Bartels-Rausch, Thorsten, Flórez Ospina, Juan Felipe, Garner, Natasha M., Iezzi, Lucia, Kilchhofer, Kevin, Laso, Andrés, Longetti, Luca, Mahrt, Fabian   +11 more
openaire   +7 more sources

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Development of the adjoint of the unified tropospheric–stratospheric chemistry extension (UCX) in GEOS-Chem adjoint v36 [PDF]

Geoscientific Model Development
Atmospheric sensitivities (gradients), quantifying the atmospheric response to emissions or other perturbations, can provide meaningful insights on the underlying atmospheric chemistry or transport processes.
I. C. Dedoussi, I. C. Dedoussi, I. C. Dedoussi, D. K. Henze, S. D. Eastham, S. D. Eastham, R. L. Speth, S. R. H. Barrett   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Interfacial chemistry of atmospheric microdroplets

npj Climate and Atmospheric Science
Microdroplets are ubiquitous atmospheric micro-environments, including clouds, sea spray, and ambient aerosols, where interfacial physicochemical properties can drive reaction kinetics distinct from those in bulk aqueous phases.
Yuwei Li, Shunyao Wang, Tianchen Qin, Yuanlong Huang   +3 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source