Results 31 to 40 of about 92,064 (262)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Implementation of the chemistry module MECCA (v2.5) in the modal aerosol version of the Community Atmosphere Model component (v3.6.33) of the Community Earth System Model [PDF]

Geoscientific Model Development, 2013
A coupled atmospheric chemistry and climate system model was developed using the modal aerosol version of the National Center for Atmospheric Research Community Atmosphere Model (modal-CAM; v3.6.33) and the Max Planck Institute for Chemistry's Module ...
M. S. Long, W. C. Keene, R. Easter, R. Sander, A. Kerkweg, D. Erickson, X. Liu, S. Ghan   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of biogenic NO emissions from soil on atmospheric chemistry over Africa: a regional modelling study [PDF]

Atmospheric Chemistry and Physics
In the context of climate change and increasing anthropogenic pressures in Africa, understanding the interactions between atmospheric chemistry, regional climate, and biogeochemical cycles is critical.
E. M. Yao, E. M. Yao, F. Solmon, M. Adon, C. Delon, C. Galy-Lacaux, G. Giuliani, B. Sauvage, V. Yoboue   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Atmospheric chemistry enhances the climate mitigation potential of tree restoration

Communications Earth & Environment
Although tree restoration, including reforestation and afforestation, can enhance carbon sequestration and help mitigate climate change, this negative forcing can be strengthened or weakened through non-carbon cycle biogeophysical factors, including ...
Robert J. Allen, Yu-Chi Lee, Antony Thomas, David Duarte, Mohima Sultana Mimi, Kai-Yuan Li, Brianna Wenzel, Joon-Gu Jeon, Olivia E. Clifton   +8 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Fast, Parallelized, GPU-accelerated Photochemical Model, XODIAC, with Built-in Equilibrium Chemistry and Multiple Chemical Networks for Exoplanetary Atmospheres

The Astrophysical Journal
The launch of the James Webb Space Telescope has delivered high-quality atmospheric observations and expanded the known chemical inventory of exoplanetary atmospheres, opening new avenues for atmospheric chemistry modeling to interpret these data.
Priyankush Ghosh, Sambit Mishra, Shubham Dey, Debayan Das, P. B. Rimmer, Liton Majumdar   +5 more
doaj   +1 more source

A química atmosférica no Brasil de 1790 a 1853

Química Nova, 2010
Atmospheric chemistry in Brazil from 1790 to 1853. Scarcely any mention is made today of investigations carried out in Brazil during the period above on the science of the atmosphere.
Adílio Jorge Marques, Carlos A. L. Filgueiras   +1 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source