Results 41 to 50 of about 92,064 (262)

Zeeman: A Deep Learning Framework for Regional Atmospheric Chemistry Forecasting

Geophysical Research Letters
Atmospheric chemistry encapsulates the emission of various pollutants, the complex chemistry reactions, and the meteorology dominant transport, which form a dynamic system that governs air quality.
Mijie Pang, Jianbing Jin, Arjo Segers, Hai Xiang Lin, Guoqiang Wang, Hong Liao, Wei Han   +6 more
doaj   +1 more source

History of Atmospheric Chemistry in Switzerland

CHIMIA
This paper presents an overview on atmospheric chemistry, beginning with international aspects since the Roman Empire, and then focusing on the developments in Switzerland.
Urs Baltensperger
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A three-dimensional atmospheric dispersion model for Mars

Progress in Earth and Planetary Science, 2021
Atmospheric local-to-regional dispersion models are widely used on Earth to predict and study the effects of chemical species emitted into the atmosphere and to contextualize sparse data acquired at particular locations and/or times. However, to date, no
D. Viúdez-Moreiras
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Multiphase Chemistry in the Atmosphere

CHIMIA
Earth’s atmosphere comprises a complex mix of gas and condensed phases, where condensed phases facilitate multiphase chemical reactions that would not occur in the gas phase alone. These reactions drive dynamic physical and chemical processes across various spatial and temporal scales, playing a crucial role in the cycling of atmospheric trace ...
Ammann, Markus, Alpert, Peter A., Artiglia, Luca, Bao, Fengxia, Bartels-Rausch, Thorsten, Flórez Ospina, Juan Felipe, Garner, Natasha M., Iezzi, Lucia, Kilchhofer, Kevin, Laso, Andrés, Longetti, Luca, Mahrt, Fabian   +11 more
openaire   +6 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Global/Regional Integrated Model System‐Chemistry Climate Model: 1. Simulation Characteristics

Earth and Space Science, 2019
This study describes the simulation characteristics of a newly developed Global/Regional Integrated Model system‐Chemistry Climate Model (GRIMs‐CCM), which is listed in Chemistry Climate Model Initiative as a participating model.
Yong‐Cheol Jeong, Sang‐Wook Yeh, Seungun Lee, Rokjin J. Park   +3 more
doaj   +1 more source