Results 191 to 200 of about 36,528 (256)

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, EarlyView.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Electrolyte‐Replacement‐Free Continuous Electrocatalytic Desalination Coupled With CO2 Reduction at Record Throughput and Low Cost

Angewandte Chemie, EarlyView.
A continuous electrocatalytic desalination system powered by CO2 electroreduction that eliminates electrolyte replacement through a self‐balancing circulating design. Using a five‐chamber architecture and an efficient cobalt‐based catalyst, it achieves ultrafast salt removal, high CO production efficiency, and stable long‐term operation, offering a ...
Man Liang, Pucheng Duan, Minzhang Li, Zhefei Wu, Lu Guo, Afzalshoh Qahramon Zarifzoda, Chengli Rong, Fuming Chen, Yuan Chen   +8 more
wiley   +2 more sources

Regulation of atmospheric circulation controlling the tropical Pacific precipitation change in response to CO₂ increases. [PDF]

Nat Commun, 2019
Sohn BJ, Yeh SW, Lee A, Lau WKM.
europepmc   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Atmospheric Circulation Patterns Associated with Extreme United States Floods Identified via Machine Learning. [PDF]

Sci Rep, 2019
Schlef KE, Moradkhani H, Lall U.
europepmc   +1 more source

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

Advanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang, Lingqing Zong, Ashish Misra, Sanjay Patel, Zi Gu   +4 more
wiley   +1 more source

The Signature of Southern Hemisphere Atmospheric Circulation Patterns in Antarctic Precipitation. [PDF]

Geophys Res Lett, 2017
Marshall GJ, Thompson DWJ, van den Broeke MR.   +2 more
europepmc   +1 more source

Summers with low Arctic sea ice linked to persistence of spring atmospheric circulation patterns. [PDF]

Clim Dyn, 2019
Kapsch ML, Skific N, Graversen RG, Tjernström M, Francis JA.   +4 more
europepmc   +1 more source

Influence of Tibetan Plateau snow cover on East Asian atmospheric circulation at medium-range time scales. [PDF]

Nat Commun, 2018
Li W, Guo W, Qiu B, Xue Y, Hsu PC, Wei J.   +5 more
europepmc   +1 more source

Embedding Chemistry and Pharmacy Into Sustainability

Angewandte Chemie International Edition, EarlyView.
Chemistry and pharmacy provide products and processes that are indispensable for our high living standard. To understand their relationship with sustainability is important to allow them to contribute to sustainability in a sustainable manner. An integrated overview of green, circular, and sustainable chemistry and pharmacy is given and how they have t
Klaus Kümmerer
wiley   +1 more source