Results 51 to 60 of about 4,161,987 (390)

Numerical simulations of aerosol radiative effects and their impact on clouds and atmospheric dynamics over southern West Africa

Atmospheric Chemistry and Physics, 2018
. Southern West Africa (SWA) is undergoing rapid and significant socioeconomic changes associated with a massive increase in air pollution. Still, the impact of atmospheric pollutants, in particular that of aerosol particles, on weather and climate in ...
K. Deetz, H. Vogel, P. Knippertz, B. Adler, Jonathan W. Taylor, H. Coe, K. Bower, S. Haslett, M. Flynn, J. Dorsey, I. Crawford, C. Kottmeier, B. Vogel   +12 more
semanticscholar   +1 more source

Cluster Dynamics of Planetary Waves [PDF]

, 2008
The dynamics of nonlinear atmospheric planetary waves is determined by a small number of independent wave clusters consisting of a few connected resonant triads.
E. Kartashova, Francius M., Kartashova E., Kartashova E., Kartashova E., Kartashova E., Kartashova E. A., Pedlosky J., Pierrehumbert R. T., V. S. L'vov   +9 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Seasonal predictions of summer compound humid heat extremes in the southeastern United States driven by sea surface temperatures

npj Climate and Atmospheric Science
Humid heat extreme (HHE) is a type of compound extreme weather event that poses severe risks to human health. Skillful forecasts of HHE months in advance are crucial for developing strategies to enhance community resilience to extreme events1,2.
Liwei Jia, Thomas L. Delworth, Xiaosong Yang, William Cooke, Nathaniel C. Johnson, Liping Zhang, Youngji Joh, Feiyu Lu, Colleen McHugh   +8 more
doaj   +1 more source

The Flexible Global Ocean‐Atmosphere‐Land System Model Grid‐Point Version 3 (FGOALS‐g3): Description and Evaluation

Journal of Advances in Modeling Earth Systems, 2020
This paper introduces the Flexible Global Ocean‐Atmosphere‐Land System Model: Grid‐Point Version 3 (FGOALS‐g3) and evaluates its basic performance based on some of its participation in the sixth phase of the Coupled Model Intercomparison Project (CMIP6 ...
Lijuan Li, Yongqiang Yu, Yanli Tang, Pengfei Lin, Jinbo Xie, Mirong Song, Li Dong, Tianjun Zhou, Li Liu, Lu Wang, Ye Pu, Xiaolong Chen, Lin Chen, Zhenghui Xie, Hongbo Liu, Lixia Zhang, Xin Huang, Tao Feng, Weipeng Zheng, Kun Xia, Hailong Liu, Jiping Liu, Yan Wang, Longhuan Wang, Binghao Jia, Feng Xie, Bin Wang, Shuwen Zhao, Zipeng Yu, Bowen Zhao, Jilin Wei   +30 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Quantifying sources of subseasonal prediction skill in CESM2

npj Climate and Atmospheric Science
Subseasonal prediction fills the gap between weather forecasts and seasonal outlooks. There is evidence that predictability on subseasonal timescales comes from a combination of atmosphere, land, and ocean initial conditions. Predictability from the land
Jadwiga H. Richter, Anne A. Glanville, Teagan King, Sanjiv Kumar, Stephen G. Yeager, Nicholas A. Davis, Yanan Duan, Megan D. Fowler, Abby Jaye, Jim Edwards, Julie M. Caron, Paul A. Dirmeyer, Gokhan Danabasoglu, Keith Oleson   +13 more
doaj   +1 more source

The Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory (SDO)

, 2011
The Atmospheric Imaging Assembly (AIA) provides multiple simultaneous high-resolution full-disk images of the corona and transition region up to 0.5 R⊙ above the solar limb with 1.5-arcsec spatial resolution and 12-second temporal resolution.
J. Lemen, A. Title, D. J. Akin, P. Boerner, C. Chou, J. Drake, D. Duncan, C. Edwards, F. Friedlaender, G. F. Heyman, N. Hurlburt, N. Katz, G. Kushner, M. Levay, R. Lindgren, D. Mathur, Edward L. McFeaters, Sarah D. Mitchell, R. Rehse, C. Schrijver, L. Springer, L. Springer, R. Stern, T. Tarbell, J. Wuelser, C. J. Wolfson, C. Yanari, J. Bookbinder, P. Cheimets, D. Caldwell, E. DeLuca, R. Gates, L. Golub, Sang C. Park, W. Podgorski, R. Bush, P. Scherrer, M. Gummin, Peter L. Smith, G. Auker, P. Jerram, P. Pool, R. Soufli, D. Windt, S. Beardsley, M. Clapp, J. Lang, N. Waltham   +47 more
semanticscholar   +1 more source

Tropical forests and global atmospheric change: a synthesis [PDF]

, 2004
We present a personal perspective on the highlights of the Theme Issue 'Tropical forests and global atmospheric change'. We highlight the key findings on the contemporary rate of climatic change in the tropics, the evidence--gained from field studies--of
Malhi, Y., Phillips, O.L.
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source