Results 51 to 60 of about 3,856,695 (383)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Seasonal predictions of summer compound humid heat extremes in the southeastern United States driven by sea surface temperatures

npj Climate and Atmospheric Science
Humid heat extreme (HHE) is a type of compound extreme weather event that poses severe risks to human health. Skillful forecasts of HHE months in advance are crucial for developing strategies to enhance community resilience to extreme events1,2.
Liwei Jia, Thomas L. Delworth, Xiaosong Yang, William Cooke, Nathaniel C. Johnson, Liping Zhang, Youngji Joh, Feiyu Lu, Colleen McHugh   +8 more
doaj   +1 more source

Internal wave coupling processes in Earth's atmosphere [PDF]

, 2014
This paper presents a contemporary review of vertical coupling in the atmosphere and ionosphere system induced by internal waves of lower atmospheric origin. Atmospheric waves are primarily generated by meteorological processes, possess a broad range of spatial and temporal scales, and can propagate to the upper atmosphere.
arxiv   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

When is a trend meaningful? Insights to carbon cycle variability from an initial-condition large ensemble

npj Climate and Atmospheric Science
Internal climate variability (ICV) creates a range of climate trajectories, which are superimposed upon the forced response. A single climate model realization may not represent forced change alone and may diverge from other realizations, as well as ...
Gordon B. Bonan, Clara Deser, William R. Wieder, Danica L. Lombardozzi, Flavio Lehner   +4 more
doaj   +1 more source

Effects of Bulk Composition on the Atmospheric Dynamics on Close-in Exoplanets [PDF]

, 2014
Super Earths and mini Neptunes likely have a wide range of atmospheric compositions, ranging from low molecular mass atmospheres of H2 to higher molecular atmospheres of water, CO2, N2, or other species.
Xi Zhang, A. Showman
semanticscholar   +1 more source

Performance Triggered Adaptive Model Reduction for Soil Moisture Estimation in Precision Irrigation

International Journal of Adaptive Control and Signal Processing, EarlyView.
ABSTRACT Accurate soil moisture information is essential for precise irrigation to enhance water use efficiency. Estimating soil moisture based on limited soil moisture sensors is especially critical for obtaining comprehensive soil moisture information when dealing with large‐scale agricultural fields.
Sarupa Debnath, Bernard Twum Agyeman, Soumya Ranjan Sahoo, Xunyuan Yin, Jinfeng Liu   +4 more
wiley   +1 more source

Quantifying sources of subseasonal prediction skill in CESM2

npj Climate and Atmospheric Science
Subseasonal prediction fills the gap between weather forecasts and seasonal outlooks. There is evidence that predictability on subseasonal timescales comes from a combination of atmosphere, land, and ocean initial conditions. Predictability from the land
Jadwiga H. Richter, Anne A. Glanville, Teagan King, Sanjiv Kumar, Stephen G. Yeager, Nicholas A. Davis, Yanan Duan, Megan D. Fowler, Abby Jaye, Jim Edwards, Julie M. Caron, Paul A. Dirmeyer, Gokhan Danabasoglu, Keith Oleson   +13 more
doaj   +1 more source

Role of Tropical Cyclones in Determining ENSO Characteristics

Geophysical Research Letters, 2023
El Niño‐Southern Oscillation (ENSO) can effectively modulate global tropical cyclone (TC) activity, but the role TCs may play in determining ENSO characteristics remains unclear.
Hui Li, Aixue Hu, Gerald A. Meehl
doaj   +1 more source

Impact of Iron Contamination on Liquid Properties and Microstructural Evolution in AlSi20

Advanced Engineering Materials, EarlyView.
Recycled aluminum is much more energy conservative and sustainable than primary aluminum. However, the iron contamination in secondary aluminum is vastly responsible for the degradation of the material properties. Herein, it is aimed to evaluate the influence of iron contamination in hypereutectic Al–Si alloy through thermodynamic as well as ...
Layla Shams Tisha, Anastasiya Toenjes, Nils Ellendt   +2 more
wiley   +1 more source