Results 61 to 70 of about 3,876,387 (253)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

University of Arizona, Institute of Atmospheric Physics, Progress Report No. 3

, 1956
This title from the Institute of Atmospheric Physics Reports collection is made available by the Department of Hydrology & Atmospheric Sciences and the University Libraries, University of Arizona.
Braham, Roscoe R., Jr.
core   +4 more sources

Constraining climate model projections with observations amplifies future runoff declines

Communications Earth & Environment
Climate models are increasingly used to inform water availability projections at regional scales. However, the models’ own runoff sensitivities—the change in runoff per unit change of precipitation or temperature—are often biased, which can degrade their
Hanjun Kim, Flavio Lehner, Katherine Dagon, David M. Lawrence, Sean Swenson, Andrew W. Wood   +5 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions

Nature Communications, 2018
The populous global land monsoon region has been suffering from extreme precipitation. Here, the authors show that limiting global warming to 1.5 °C instead of 2 °C could reduce areal and population exposures to baseline once-in-20-year rainfall extremes
Wenxia Zhang, Tianjun Zhou, Liwei Zou, Lixia Zhang, Xiaolong Chen   +4 more
doaj   +1 more source

Improvements in Wintertime Surface Temperature Variability in the Community Earth System Model Version 2 (CESM2) Related to the Representation of Snow Density

Journal of Advances in Modeling Earth Systems, 2022
The Community Earth System Model (CESM) is widely used for the prediction and understanding of climate variability and change. Accurate simulation of the behavior of near surface air temperature (T2m) is critical in such a model for addressing societally
Isla R. Simpson, David M. Lawrence, Sean C. Swenson, Cecile Hannay, Karen A. McKinnon, John E. Truesdale   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Current Status and Challenges in Data Collection for Aerospace Coatings Deposited by Plasma Spraying

Advanced Engineering Materials, EarlyView.
An innovative approach has been integrated into the GRENAT project to optimize plasma spraying and coating performance. Raw materials are accelerated and melted in the plasma generated by torches, creating coatings. Monitoring sensors collect process data which are combined with ex situ characterization data.
Lila Randriamananjara, Vincent Rat, Quentin Dubreuil, Patrice Valorge, Simon Goutier, Alain Denoirjean, Olivier Messe, Céline Ruelle, Jean‐Philippe Poli   +8 more
wiley   +1 more source

The Role of Nonlinear Energy Advection in Forming Asymmetric Structure of ENSO Teleconnections Over the North Pacific and North America

Geophysical Research Letters, 2023
In boreal winter, the El Niño/Southern Oscillation (ENSO)‐induced Pacific‐North American (PNA) teleconnection pattern is farther westward during La Niña relative to that in El Niño, causing discernible distinct climate implications.
Ya Wang, Kaiming Hu, Gang Huang, Weichen Tao   +3 more
doaj   +1 more source