Results 41 to 50 of about 72,710 (267)

Heating and dynamics of the Solar atmosphere

CoRR, 2023
The solar atmosphere shows anomalous variation in temperature, starting from the 5500 K photosphere to the million-degree Kelvin corona. The corona itself expands into the interstellar medium as the free streaming solar wind, which modulates and impacts the near-Earth space weather.
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Role of Tropical Cyclones in Determining ENSO Characteristics

Geophysical Research Letters, 2023
El Niño‐Southern Oscillation (ENSO) can effectively modulate global tropical cyclone (TC) activity, but the role TCs may play in determining ENSO characteristics remains unclear.
Hui Li, Aixue Hu, Gerald A. Meehl
doaj   +1 more source

Atmospheric Dynamics of Terrestrial Planets [PDF]

, 2018
The solar system presents us with a number of planetary bodies with shallow atmospheres that are sufficiently Earth-like in their form and structure to be termed “terrestrial.” These atmospheres have much in common, in having circulations that are driven primarily by heating from the Sun and radiative cooling to space, which vary markedly with latitude.
Read, P. L., Lewis, S. R., Vallis, G. K.
openaire   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Atmospheric Dynamics [PDF]

Eos, Transactions American Geophysical Union, 2000
The subject of atmospheric dynamics is featured in a large and steadily increasing number of textbooks. John Green's Atmospheric Dynamics is distinctly different from other books on the topic in several respects. Most important, the reader is expected to have prior knowledge of atmospheric dynamics; significant knowledge in some aspects.
openaire   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions

Nature Communications, 2018
The populous global land monsoon region has been suffering from extreme precipitation. Here, the authors show that limiting global warming to 1.5 °C instead of 2 °C could reduce areal and population exposures to baseline once-in-20-year rainfall extremes
Wenxia Zhang, Tianjun Zhou, Liwei Zou, Lixia Zhang, Xiaolong Chen   +4 more
doaj   +1 more source