Results 61 to 70 of about 4,161,987 (390)

When is a trend meaningful? Insights to carbon cycle variability from an initial-condition large ensemble

open access: yesnpj Climate and Atmospheric Science
Internal climate variability (ICV) creates a range of climate trajectories, which are superimposed upon the forced response. A single climate model realization may not represent forced change alone and may diverge from other realizations, as well as ...
Gordon B. Bonan   +4 more
doaj   +1 more source

Role of Tropical Cyclones in Determining ENSO Characteristics

open access: yesGeophysical Research Letters, 2023
El Niño‐Southern Oscillation (ENSO) can effectively modulate global tropical cyclone (TC) activity, but the role TCs may play in determining ENSO characteristics remains unclear.
Hui Li, Aixue Hu, Gerald A. Meehl
doaj   +1 more source

Atmospheric Dynamics Leading to West European Summer Hot Temperatures Since 1851

open access: yesComplex, 2018
Summer hot temperatures have many impacts on health, economy (agriculture, energy, transports) and ecosystems. In western Europe, the recent summers of 2003 and 2015 were exceptionally warm.
C. Alvarez-Castro   +2 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Beryllium-7 and Lead-210 in the atmosphere and surface snow over the Greenland ice sheet in the summer of 1989 [PDF]

open access: yes, 1990
The concentrations of 7Be and 210Pb were measured in surface air and fresh and aging snow samples from Summit (72°20′N, 38°45′W) and Dye 3 (65°10′N, 44°45′W) Greenland, during June and July 1989.
Dibb, Jack E.
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Atmospheric Dynamics of Hot Exoplanets [PDF]

open access: yes, 2014
The characterization of exoplanetary atmospheres has come of age in the past decade, as astronomical techniques now allow for albedos, chemical abundances, temperature profiles and maps, rotation periods, and even wind speeds to be measured.
K. Heng, A. Showman
semanticscholar   +1 more source

Unstationnary control of a launcher using observer-based structures [PDF]

open access: yes, 2003
This paper deals with the design of a gain-scheduled controller for the attitude control of a launcher during atmospheric flight. The design is characterized by classical requirements such as phase/gain margins and flexible mode attenuations as well as
Alazard, Daniel   +2 more
core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

open access: yesFEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy