Results 71 to 80 of about 4,028,785 (396)
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Advanced Biology, EarlyView.In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins +2 more
wiley +1 more source
Reduced exposure to extreme precipitation from 0.5 °C less warming in global land monsoon regions
Nature Communications, 2018 The populous global land monsoon region has been suffering from extreme precipitation. Here, the authors show that limiting global warming to 1.5 °C instead of 2 °C could reduce areal and population exposures to baseline once-in-20-year rainfall extremes
Wenxia Zhang +4 more
doaj +1 more source
Journal of Advances in Modeling Earth Systems, 2022 The Community Earth System Model (CESM) is widely used for the prediction and understanding of climate variability and change. Accurate simulation of the behavior of near surface air temperature (T2m) is critical in such a model for addressing societally
Isla R. Simpson +5 more
doaj +1 more source
Advanced Biology, EarlyView.This study optimized a cell‐based ELISA for HIT antibody detection using PF4‐coated breast cancer cells (MDA‐MB‐231). Enhanced binding was observed at 50 mM NaCl and 4% paraformaldehyde fixation. Live MDA‐MB‐231 and HCT‐116 cells demontrated superior sensitivity and specificity, providing a promising platelet‐free alternative for clinical HIT diagnosis.
Li‐Yu Chen +4 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Geophysical Research Letters, 2023 In boreal winter, the El Niño/Southern Oscillation (ENSO)‐induced Pacific‐North American (PNA) teleconnection pattern is farther westward during La Niña relative to that in El Niño, causing discernible distinct climate implications.
Ya Wang +3 more
doaj +1 more source
Dynamics of Massive Atmospheres
The Astrophysical Journal, 2017 Abstract The many recently discovered terrestrial exoplanets are expected to hold a wide range of atmospheric masses. Here the dynamic-thermodynamic effects of atmospheric mass on atmospheric circulation are studied using an idealized global circulation model by systematically varying the atmospheric surface pressure.
Rei Chemke, Yohai Kaspi
openaire +2 more sources
Atmospheric Dynamics is the Largest Source of Uncertainty in Future Winter European Rainfall
, 2018 The IPCC Fifth Assessment Report highlighted large uncertainty in European precipitation changes in the coming century. This paper investigates the sources of intermodel differences using CMIP5 model European precipitation data.
D. Fereday +3 more
semanticscholar +1 more source
Nature Communications, 2020 Agriculture (e.g., rice paddies) has been considered one of the main emission sources responsible for the sudden rise of atmospheric methane concentration (XCH4) since 2007, but remains debated.
Geli Zhang +7 more
semanticscholar +1 more source