Results 41 to 50 of about 1,003,860 (311)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Atmospheric effects and spurious signals in GPS analyses [PDF]
, 2015 Improvements in the analyses of Global Positioning System (GPS) observations yield resolvable millimeter to submillimeter differences in coordinate estimates, thus providing sufficient resolution to distinguish subtle differences in analysis ...
Tregoning, Paul +1 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Atmospheric Effects on InSAR Measurements and Their Mitigation
Sensors, 2008 Interferometric Synthetic Aperture Radar (InSAR) is a powerful technology for observing the Earth surface, especially for mapping the Earth's topography and deformations.
Jiang-ping Long +4 more
doaj +1 more source
The Effects of Atmospheric Dispersion on High-Resolution Solar Spectroscopy
, 2006 We investigate the effects of atmospheric dispersion on observations of the Sun at the ever-higher spatial resolutions afforded by increased apertures and improved techniques.
A.T. Young +29 more
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Atmospheric effects on continuous-variable quantum key distribution
New Journal of Physics, 2018 Compared to fiber continuous-variable quantum key distribution (CVQKD), atmospheric link offers the possibility of a broader geographical coverage and more flexible transmission.
Shiyu Wang +3 more
doaj +1 more source
Summary report of the Simulation Committee [PDF]
, 1977 Topics discussed by the simulation committee included: (1) simulators and their uses; (2) atmospheric disturbance modeling requirements; (3) Status of simulators' capabilities for modeling disturbances; and (4) status of atmospheric disturbance models ...
Kurkowski, R. L.
core +1 more source
The Infrared Imaging Spectrograph (IRIS) for TMT: the atmospheric dispersion corrector [PDF]
, 2010 We present a conceptual design for the atmospheric dispersion corrector (ADC) for TMT's Infrared Imaging Spectrograph (IRIS). The severe requirements of this ADC are reviewed, as are limitations to observing caused by uncorrectable atmospheric effects ...
Bauman, Brian J. +6 more
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source