Results 51 to 60 of about 178,994 (266)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Deep-learning-based prediction of precipitable water vapor in the Chajnantor area

Astronomy & Astrophysics
Context. Astronomical observations at millimeter and submillimeter wavelengths strongly depend on the amount of precipitable water vapor (PWV) in the atmosphere, which directly affects the sky transparency and decreases the signal-to-noise ratio of the ...
Matus-Bello Alison, Restrepo Silvia E., Bustos Ricardo, Hu Yi, Du Fujia, Cariñe Jaime, García Pablo, Maldonado Javier, Reeves Rodrigo, Shang Zhaohui   +9 more
doaj   +1 more source

Atmospheric Effects at Sunset [PDF]

Nature, 1888
ON Sunday, January 8, upon leaving the house at half-past four in the afternoon, I observed that the clouds were suffused with a kind of pink or lurid coppery tinge, a sort of angry sunset tint spread over the whole sky. The clouds were of the stratus type which is common in a winter anticyclone, but were moving or rather driving with a swiftness quite
openaire   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

On-sky demonstration of reinforcement learning for adaptive optics control

Astronomy & Astrophysics
Context. Reinforcement-learning- (RL-) based algorithms have recently emerged as a promising approach for adaptive optics (AO) control. In simulations and laboratory experiments, they have demonstrated robustness to real-world effects such as photon and ...
Nousiainen J., Chambouleyron V., Neichel B., Cetre S., Sauvage J.-F., Alagao A., Kasper M., Dray J., Fétick R., Engler B.   +9 more
doaj   +1 more source

Karhunen-Loève Basis Functions Of Kolmogorov Turbulence In The Sphere (Baltic Astronomy, 17, 383, 2008, Erratum)

Open Astronomy, 2010
The previously published factor, which scales the matrix elements of the eigenvalue equation as a finite outer scale of the von-Kármán model is switched on, is corrected.
Mathar Richard J.
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source