Results 41 to 50 of about 178,994 (266)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Analysis of Ice Phenology of Middle and Large Lakes on the Tibetan Plateau

Sensors, 2023
Considered as a sensitive indicator of climate change, lake ice phenology can have significant influences on regional climate by affecting lake-atmosphere energy and water exchange.
Lijun Sun, Binbin Wang, Yaoming Ma, Xingdong Shi, Yan Wang   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Central flashes during stellar occultations

Astronomy & Astrophysics
Context. Central flashes may occur during stellar occultations by objects in the Solar System. Aims. Catalog diffraction effects on the flash with point-like stars, monochromatic waves, and different cases of spherical transparent atmosphere; describe ...
Sicardy B., Dettwiller L.
doaj   +3 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Atmospheric effects on continuous-variable quantum key distribution

New Journal of Physics, 2018
Compared to fiber continuous-variable quantum key distribution (CVQKD), atmospheric link offers the possibility of a broader geographical coverage and more flexible transmission.
Shiyu Wang, Peng Huang, Tao Wang, Guihua Zeng   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Assessment of Daytime Sky Quality and Atmospheric Refractive Index ( ) Analysis at Pico dos Dias Observatory

The Astrophysical Journal Supplement Series
Ground-based astronomical and solar observations are strongly influenced by atmospheric turbulence, a dynamic phenomenon that degrades optical resolution through refractive index fluctuations.
Edith T. Cuadros, Adriano P. Almeida, Franciele Carlesso, David Pareja-Quispe, Fernando L. Guarnieri, Alisson Dal Lago, Saulo R. Gargaglioni, Luis E. A. Vieira   +7 more
doaj   +1 more source

Atmospheric Effects on InSAR Measurements and Their Mitigation

Sensors, 2008
Interferometric Synthetic Aperture Radar (InSAR) is a powerful technology for observing the Earth surface, especially for mapping the Earth's topography and deformations.
Jiang-ping Long, Guang-cai Feng, Jian-jun Zhu, Zhi-wei Li, Xiao-li Ding   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source