Results 61 to 70 of about 1,003,860 (311)

Summer Lake Destratification Phenomenon: A Peculiar Deep Lake on the Tibetan Plateau

Frontiers in Earth Science, 2022
Lake water temperature and the related thermal structure influence not only the provision of ecosystem services in lacustrine environments but also the interactions with regional climate. However, continuous lake temperature monitoring across the Tibetan
Rongmingzhu Su, Rongmingzhu Su, Zhipeng Xie, Weiqiang Ma, Weiqiang Ma, Weiqiang Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Yaoming Ma, Binbin Wang, Wei Hu, Wei Hu, Zhongbo Su   +15 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

On the impact of high-resolution, high-frequency meteorological forcing on Denmark Strait ocean circulation [PDF]

, 2009
This paper quantifies and discusses the impact of high-resolution, high-frequency atmospheric forcing on the ocean circulation in the vicinity of the Denmark Strait.
Haine, TWN, Moore, GWK, Renfrew, IA, Zhang, S   +3 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Deep-learning-based prediction of precipitable water vapor in the Chajnantor area

Astronomy & Astrophysics
Context. Astronomical observations at millimeter and submillimeter wavelengths strongly depend on the amount of precipitable water vapor (PWV) in the atmosphere, which directly affects the sky transparency and decreases the signal-to-noise ratio of the ...
Matus-Bello Alison, Restrepo Silvia E., Bustos Ricardo, Hu Yi, Du Fujia, Cariñe Jaime, García Pablo, Maldonado Javier, Reeves Rodrigo, Shang Zhaohui   +9 more
doaj   +1 more source

The effects of CO2, climate and land-use on terrestrial carbon balance, 1920-1992: An analysis with four process-based ecosystem models [PDF]

, 2001
The concurrent effects of increasing atmospheric CO2 concentration, climate variability, and cropland establishment and abandonment on terrestrial carbon storage between 1920 and 1992 were assessed using a standard simulation protocol with four process ...
A. D. McGuire, A. Schloss, B. Moore, Ball, Battle, Bender, Braswell, Bruno, Cao, Cheney, Ciais, Collatz, Cramer, D. W. Kicklighter, DeLucia, Denning, Denning, Esser, Etheridge, F. Joos, Farquhar, Feely, Foley, Foley, Francey, Freeze, G. Esser, H. Tian, Harden, Haxeltine, Heimann, Heimann, Heimann, Holland, Houghton, Houghton, Hulme, Hulme, I. C. Prentice, Indermuehle, J. Foley, J. Kaplan, J. M. Melillo, J. S. Clein, Jones, Joos, Joos, Kaminski, Kauppi, Kauppi, Keeling, Keeling, Keeling, Keeling, Keeling, Keeling, Kicklighter, Kicklighter, Kindermann, Kling, Kohlmaier, Kucharik, L. J. Williams, Langenfelds, Lee, Lloyd, Lloyd, Long, Loveland, M. Heimann, Maier-Reimer, Malmstrom, McGuire, McGuire, McGuire, McGuire, Melillo, Melillo, Meyer, Monsi, Monteith, N. Ramankutty, Nadelhoffer, Neilson, Pan, Pan, Petit, Pollard, Prentice, Prentice, R. A. Meier, R. Dargaville, Raich, Ramankutty, Ramankutty, Randerson, Randerson, Rastetter, Rayner, S. Sitch, Schimel, Schimel, Schimel, Schlesinger, Sellers, Shaver, Smith, Stallard, T. Reichenau, Tans, Tian, Tian, Tian, Tian, Townsend, U. Wittenberg, Vukicevic, Vörösmarty, Wigley, Zimov, Zobler   +120 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Sentinel-2 forest typology mapping in Central Africa: assessing deep learning and image preprocessing effects

Frontiers in Remote Sensing
IntroductionCentral African forests are key reservoirs of carbon and biodiversity. Developing a detailed, spatially explicit typology of forest types is essential for monitoring and conservation.
Gaëlle Viennois, Hadrien Tulet, Paul Tresson, Pierre Ploton, Pierre Couteron, Nicolas Barbier   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source