Results 21 to 30 of about 225,035 (267)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Observations and modeling of the boundary layer accompanying a tropical squall line [PDF]

open access: yes, 1983
April 1983.Sponsored by the National Science Foundation, Division of Atmospheric Sciences ATM-8015347.Sponsored by the National Science Foundation, Division of Atmospheric Sciences ATM ...
Department of Atmospheric Science, Colorado State University, publisher   +2 more
core  

A consistent molecular hydrogen isotope chemistry scheme based on an independent bond approximation

open access: yes, 2009
The isotopic composition of molecular hydrogen (H<sub>2</sub>) produced by photochemical oxidation of methane (CH<sub>4</sub>) and Volatile Organic Compounds (VOCs) is a key quantity in the global isotope budget of (H<sub>2 ...
Sub Atmospheric physics and chemistry   +8 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The addition of the direct radiative effect of atmospheric aerosols into the Regional Atmospheric Modeling System (RAMS) [PDF]

open access: yes, 2005
Includes bibliographical references.DoD Center for Geosciences/Atmospheric Research under grant DAAD19-02-2 ...
Cotton, William R., 1940-, author   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Atmospheric science: Cloudy, with a chance of science [PDF]

open access: yesNature, 2009
When American and Chinese scientists agreed to measure pollution and dust over China, nobody foresaw how difficult it would be. Jane Qiu reports.
openaire   +1 more source

Diagnostic tests of models for the thermal structure of the non-precipitating convective boundary layer [PDF]

open access: yes, 1974
April 1974.Sponsored by National Science Foundation, Atmospheric Sciences Section GA-33182.Sponsored by National Science Foundation, Atmospheric Sciences Section GA ...
Department of Atmospheric Science, Colorado State University, publisher   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Linear spectral model of tropical mesoscale systems [PDF]

open access: yes, 1979
June, 1979.Sponsored by the Global Atmospheric Research Program, National Science Foundation and the GATE Project Office, NOAA ATM 77-15369.Sponsored by the Global Atmospheric Research Program, National Science Foundation and the GATE Project Office ...
Silva Dias, Maria Faus, author   +1 more
core  

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