Results 21 to 30 of about 991,880 (304)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
UTSI atmospheric science program [PDF]
, 1977 Two areas of research were carried out concerned with meteorological and environmental inputs to aviation systems. One effort dealt with the investigation of wind fields about bluff geometries typical of buildings or other man made obstructions to the ...
Frost, W.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Terrestrial, Atmospheric and Oceanic Sciences, 2015 This study examines the spatio-temporal variations in the sea-surface chlorophyll-a (Chl-a) concentration and their associated underlying driving forces in the northern South China Sea (SCS) from 2004 - 2010. A stratified analysis method and the Moderate
Meihong Fang +4 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Terrestrial, Atmospheric and Oceanic Sciences, 2015 This paper presents the first field, geochemical and geophysical information on the recently recognized Early Cretaceous Balud Ophiolitic Complex (BOC) in the island of Masbate in the Central Philippines.
Pearlyn C. Manalo +7 more
doaj +1 more source
Exomars entry and descent science [PDF]
, 2008 The entry, descent and landing of ExoMars offer a rare (once-per-mission) opportunity to perform in situ investigation of the martian environment over a wide altitude range.
Aboudan, A. +9 more
core
Laser Guide Star for 3.6m and 8m telescopes: Performances and astrophysical implications [PDF]
, 1997 We have constructed an analytical model to simulate the behavior of an adaptive optics system coupled with a sodium laser guide star. The code is applied to a 3.6-m and 8m class telescopes. The results are given in terms of Strehl ratio and full width at
Foy, R. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Atmosphere, 2019 The upper atmosphere of Mars is constantly perturbed by small-scale gravity waves propagating from below. As gravity waves strongly affect the large-scale dynamics and thermal state, constraining their statistical characteristics is of great importance ...
David Jesch +4 more
doaj +1 more source