Results 31 to 40 of about 225,035 (267)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparison between the measured and calculated spectral characteristics of shortwave radiation in the free atmosphere over the desert (from the data of the CAENEX-70 expeditions) [PDF]

, 1976
This contribution is one in a series of reports which will be published jointly as an Atmospheric science paper, from the Dept. of Atmospheric Science, Colorado State University, Fort Collins, and in the Transactions of the Main Geophysical Observatory ...
Department of Atmospheric Science, Colorado State University, publisher, Kondratyev, K. Ya, author   +1 more
core  

What can 14 CO measurements tell us about OH?

, 2008
The possible use of 14CO measurements to constrain hydroxyl radical (OH) concentrations in the atmosphere is investigated. 14CO is mainly produced in the upper atmosphere from cosmic radiation.
Mak, J., Bergamaschi, P., Krol, M.C., Dep Natuurkunde, Meirink, J., Marine and Atmospheric Research, Meirink, J.F., Lowe, D.   +7 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Four-dimensional variational data assimilation for inverse modelling of atmospheric methane emissions: method and comparison with synthesis inversion

, 2008
A four-dimensional variational (4D-Var) data assimilation system for inverse modelling of atmospheric methane emissions is presented. The system is based on the TM5 atmospheric transport model.
Bergamaschi, P., M. C. Krol, P. Bergamaschi, J. F. Meirink, Krol, M.C., Dep Natuurkunde, Meirink, J., Marine and Atmospheric Research, Meirink, J.F., Krol, M. C., Meirink, J. F.   +10 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

GATE phase III mean synoptic-scale radiative convergence profiles [PDF]

, 1980
March, 1980.Sponsored by the Global Atmospheric Research Program, National Science Foundation and the GARP Atlantic Tropical Experiment (GATE) Project Office, NOAA ATM 78-05743.Sponsored by the Global Atmospheric Research Program, National Science ...
Department of Atmospheric Science, Colorado State University, publisher, Cox, Stephen K., author, Ackerman, Steven A., author   +2 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Tropospheric radiative divergence during phase III of the GARP Atlantic Tropical Experiment (GATE) [PDF]

, 1978
June 1978.Sponsored by the Global Atmospheric Research Program, National Science Foundation and the GARP Atlantic Tropical Experiment (GATE) Project Office, NOAA ATM 77-15369.Sponsored by the Global Atmospheric Research Program, National Science ...
Department of Atmospheric Science, Colorado State University, publisher, Griffith, Keith T., author, Cox, Stephen K., author   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source