Results 31 to 40 of about 248,938 (315)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Geochemical and Geophysical Characteristics of the Balud Ophiolitic Complex (BOC), Masbate Island, Philippines: Implications for its Generation, Evolution and Emplacement

Terrestrial, Atmospheric and Oceanic Sciences, 2015
This paper presents the first field, geochemical and geophysical information on the recently recognized Early Cretaceous Balud Ophiolitic Complex (BOC) in the island of Masbate in the Central Philippines.
Pearlyn C. Manalo, Carla B. Dimalanta, Decibel V. Faustino-Eslava, Betchaida D. Payot, Noelynna T. Ramos, Karlo L. Queaño, Americus D. C. Perez, and Graciano P. Yumul Jr.   +7 more
doaj   +1 more source

Design of an axisymmetric primitive equation tropical cyclone model [PDF]

, 1976
December 1976.Includes bibliographical references (pages 67-69).Sponsored by the Global Atmospheric Research Program, Climate Dynamics Research Section, National Science Foundation DES 74-11438.Sponsored by the Global Atmospheric Research Program ...
Department of Atmospheric Science, Colorado State University, publisher, Hack, James J., author, Schubert, Wayne H., author   +2 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Density Fluctuations in the Lower Thermosphere of Mars Retrieved From the ExoMars Trace Gas Orbiter (TGO) Aerobraking

Atmosphere, 2019
The upper atmosphere of Mars is constantly perturbed by small-scale gravity waves propagating from below. As gravity waves strongly affect the large-scale dynamics and thermal state, constraining their statistical characteristics is of great importance ...
David Jesch, Alexander S. Medvedev, Francesco Castellini, Erdal Yiğit, Paul Hartogh   +4 more
doaj   +1 more source

Observations and modeling of the boundary layer accompanying a tropical squall line [PDF]

, 1983
April 1983.Sponsored by the National Science Foundation, Division of Atmospheric Sciences ATM-8015347.Sponsored by the National Science Foundation, Division of Atmospheric Sciences ATM ...
Department of Atmospheric Science, Colorado State University, publisher, Johnson, Richard H., author, Nicholls, Melville, author   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The Sub-Crustal Stress Field in the Taiwan Region

Terrestrial, Atmospheric and Oceanic Sciences, 2015
We investigate the sub-crustal stress in the Taiwan region. A tectonic configuration in this region is dominated by a collision between the Philippine oceanic plate and the Eurasian continental margin.
Robert Tenzer and Mehdi Eshagh
doaj   +1 more source

The addition of the direct radiative effect of atmospheric aerosols into the Regional Atmospheric Modeling System (RAMS) [PDF]

, 2005
Includes bibliographical references.DoD Center for Geosciences/Atmospheric Research under grant DAAD19-02-2 ...
Cotton, William R., 1940-, author, Department of Atmospheric Science, Colorado State University, publisher, Stokowski, David, author   +2 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source