Results 31 to 40 of about 991,880 (304)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Sub-Crustal Stress Field in the Taiwan Region
Terrestrial, Atmospheric and Oceanic Sciences, 2015 We investigate the sub-crustal stress in the Taiwan region. A tectonic configuration in this region is dominated by a collision between the Philippine oceanic plate and the Eurasian continental margin.
Robert Tenzer and Mehdi Eshagh
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Remote Sensing, 2023 Most lidars used for cloud observations have the range resolution of about 10 m, so they are incapable of resolving submeter-scale processes that are crucial to cloud evolution.
Fan Yang +9 more
doaj +1 more source
Atmospheric Circulation of Terrestrial Exoplanets [PDF]
, 2013 The investigation of planets around other stars began with the study of gas giants, but is now extending to the discovery and characterization of super-Earths and terrestrial planets.
Kaspi, Yohai +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Planetary Science Journal, 2023 In this study, we employ and modify the Lorenz energy cycle (LEC) framework as another way to understand the atmospheric circulation on tidally locked terrestrial planets. It well describes the atmospheric general circulation in the perspective of energy
Shuang Wang, Jun Yang
doaj +1 more source
Implications of Atmospheric Differential Refraction for Adaptive Optics Observations [PDF]
, 2002 Many adaptive optics systems operate by measuring the distortion of the wavefront in one wavelength range and performing the scientific observations in a second, different wavelength range.
Roe, Henry G.
core +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Five Mars Years of Cloud Observations at Gale Crater: Opacities, Variability, and Ice Crystal Habits
The Planetary Science JournalWe update the record of cloud opacity observations conducted by the Mars Science Laboratory (MSL) Curiosity rover to cover the first five Mars Years (MYs) of the mission ( L _s = 160° of MY 31 to L _s = 160° of MY 36).
Conor W. Hayes +5 more
doaj +1 more source