Results 51 to 60 of about 248,938 (315)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Water Resources Response to Climate and Land-Cover Changes in a Semi-Arid Watershed, New Mexico, USA

Terrestrial, Atmospheric and Oceanic Sciences, 2015
This research evaluates a climate-land cover-water resources interconnected system in a semi-arid watershed with minimal human impact from 1970 - 2009. We found _ increase in temperature and 10.9% decrease in precipitation.
Joonghyeok Heo, Jaehyung Yu, John R. Giardino, and Huidae Cho   +3 more
doaj   +1 more source

Millions of historical monthly rainfall observations taken in the UK and Ireland rescued by citizen scientists

Geoscience Data Journal, 2023
Recovering additional historical weather observations from known archival sources will improve the understanding of how the climate is changing and enable detailed examination of unusual events within the historical record. The UK National Meteorological
Ed Hawkins, Stephen Burt, Mark McCarthy, Conor Murphy, Catherine Ross, Mike Baldock, John Brazier, Gill Hersee, Jacqui Huntley, Richard Meats, John O’Grady, Ian Scrimgeour, Tim Silk   +12 more
doaj   +1 more source

GATE phase III mean synoptic-scale radiative convergence profiles [PDF]

, 1980
March, 1980.Sponsored by the Global Atmospheric Research Program, National Science Foundation and the GARP Atlantic Tropical Experiment (GATE) Project Office, NOAA ATM 78-05743.Sponsored by the Global Atmospheric Research Program, National Science ...
Department of Atmospheric Science, Colorado State University, publisher, Cox, Stephen K., author, Ackerman, Steven A., author   +2 more
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Dryness Indices Based on Remotely Sensed Vegetation and Land Surface Temperature for Evaluating the Soil Moisture Status in Cropland-Forest-Dominant Watersheds

Terrestrial, Atmospheric and Oceanic Sciences, 2015
The Temperature Vegetation Dryness Index (TVDI) was derived from the relationship between remotely sensed vegetation indices and land surface temperature (TS) in this study for assessing the soil moisture status at regional scale in South Korea. The Leaf
Heewon Moon and Minha Choi
doaj   +1 more source

Mathematics in Atmospheric Sciences: An Overview [PDF]

, 2009
Several sectors of human activities rely on weather forecasts to plan in preparation of high impact weather events like snow storms, hurricanes or heat waves. Climate studies are needed to make decisions about the long-term development in agriculture, transport and land development.
openaire   +1 more source

Tropospheric radiative divergence during phase III of the GARP Atlantic Tropical Experiment (GATE) [PDF]

, 1978
June 1978.Sponsored by the Global Atmospheric Research Program, National Science Foundation and the GARP Atlantic Tropical Experiment (GATE) Project Office, NOAA ATM 77-15369.Sponsored by the Global Atmospheric Research Program, National Science ...
Department of Atmospheric Science, Colorado State University, publisher, Griffith, Keith T., author, Cox, Stephen K., author   +2 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source