Results 51 to 60 of about 489,788 (350)

Concentrations and isotope ratios of helium and other noble gases in the Earth's atmosphere during 1978-2011

, 2012
The evolution of the atmospheric noble gas composition during the past few decades has hardly been studied because, in contrast to many other atmospheric gases, systematic time-series measurements have not been available.
Colin Maden, L. Paul Steele, Martin K. Vollmer, Matthias S. Brennwald, Nadia Vogel, Ray Langenfelds, Rolf Kipfer, Simon Figura   +7 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

High-Resolution Remote Sensing of the Gradient Richardson Number in a Megacity Boundary Layer

Remote Sensing
The Gradient Richardson Number (Ri) is an important parameter for appraising the stability and turbulence exchange at the atmospheric boundary layer (ABL). However, high-resolution measurements of Ri profiles are rarely reported, especially in megacities.
Simin Yang, Yongjing Ma, Wenyu Zhang, Xinbing Ren, Kecheng Peng, Masroor Ahmad, Danjie Jia, Dandan Zhao, Lingbin Kong, Yining Ma, Jinyuan Xin   +10 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Extinction correction and on-sky calibration of SCUBA-2

, 2010
Commissioning of SCUBA-2 included a program of skydips and observations of calibration sources intended to be folded into regular observing as standard methods of source flux calibration and to monitor the atmospheric opacity and stability.
Bintley, Dan, Dempsey, Jessica T., Friberg, Per, Holland, Wayne S., Jenness, Tim   +4 more
core   +1 more source

A wind field downscaling strategy based on domain segmentation and transfer functions [PDF]

, 2018
This paper presents a novel methodology for mesoscale‐to‐microscale downscaling of near‐surface wind fields. The model chain consists on the Weather Research and Forecast mesoscale model and the Alya‐CFDWind microscale model (assuming neutral stability).
Avila, Matias, Barcons, Jordi, Folch, Arnau   +2 more
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Stability of the Submillimeter Brightness of the Atmosphere Above Mauna Kea, Chajnantor and the South Pole

, 2002
The summit of Mauna Kea in Hawaii, the area near Cerro Chajnantor in Chile, and the South Pole are sites of large millimeter or submillimeter wavelength telescopes.
Chamberlin R. A., E. Schartman, J. B. Peterson, K. M. Peterson, M. J. O’Kelly, P. A. R. Ade, R. A. Chamberlin, S. J. E. Radford   +7 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source