Results 61 to 70 of about 271,983 (269)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Deep-living and diverse Antarctic seaweeds as potentially important contributors to global carbon fixation

Communications Earth & Environment
Global models predict that Antarctica has little suitable habitat for macroalgae and that Antarctic macroalgae therefore make a negligible contribution to global carbon fixation. However, coastal surveys are rare at southern polar latitudes (beyond 71° S)
Leigh W. Tait, Caroline Chin, Wendy Nelson, Steve George, Peter Marriott, Richard L. O’Driscoll, Miles Lamare, Victoria S. Mills, Vonda J. Cummings   +8 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effects of in situ experimental warming on metabolic expression in a soft sediment bivalve

Scientific Reports
Ocean surface temperatures and the frequency and intensity of marine heatwaves are increasing worldwide. Understanding how marine organisms respond and adapt to heat pulses and the rapidly changing climate is crucial for predicting responses of valued ...
Orlando Lam-Gordillo, Emily J. Douglas, Sarah F. Hailes, Vonda Cummings, Andrew M. Lohrer   +4 more
doaj   +1 more source

The Water and Atmospheric Resources Monitoring (WARM) Network [PDF]

, 1995
The Illinois State Water Survey, headquartered in Champaign on the campus of the University of Illinois, is the primary agency in Illinois concerned with the measurement and evaluation of water resources. Research and service programs assess and evaluate
Illinois State Water Survey
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparative biology of the grenadiers Macrourus caml and M. whitsoni in the Ross Sea region, Antarctica

Frontiers in Marine Science, 2022
The grenadiers Macrourus caml and M. whitsoni form a significant bycatch component of longline fisheries for Antarctic toothfish (Dissostichus mawsoni) in the Southern Ocean.
Bradley R. Moore, Bradley R. Moore, Steven J. Parker, Peter M. Marriott, Colin Sutton, Matthew H. Pinkerton   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A national flood awareness system for ungauged catchments in complex topography: The case of development, communication and evaluation in New Zealand

Journal of Flood Risk Management
Effectively forecasting and communicating flood hazards at national or continental scales is critical to reducing impacts of flooding. Yet, it remains a challenge due to the predominance of ungauged catchments in often complex and steep terrain.
Céline Cattoën, Jono Conway, Nava Fedaeff, Daniel Lagrava, Paula Blackett, Kelsey Montgomery, Ude Shankar, Trevor Carey‐Smith, Stuart Moore, Andrea Mari, Tilmann Steinmetz, Sam Dean   +11 more
doaj   +1 more source

Global modelling of H₂ mixing ratios and isotopic compositions with the TM5 model [PDF]

, 2011
The isotopic composition of molecular hydrogen (H2) contains independent information for constraining the global H2 budget. To explore this, we have implemented hydrogen sources and sinks, including their stable isotopic composition and isotope ...
Langenfelds, R.L., G. Pieterse, T. Röckmann, L. P. Steele, Pieterse, G., Afd Marine and Atmospheric Research, Marine and Atmospheric Research, Steele, L.P., Röckmann, T., Krummel, P.B., Sub Atmospheric physics and chemistry, M. C. Krol, P. B. Krummel, Krol, M.C., R. L. Langenfelds, A. M. Batenburg, Batenburg, A.M.   +16 more
core   +1 more source