Results 71 to 80 of about 271,983 (269)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Intercomparison of Water Vapor Data Measured with Lidar during IHOP_2002. Part II: Airborne-to-Airborne Systems [PDF]

, 2007
The dataset of the International H2O Project (IHOP_2002) gives the first opportunity for direct intercomparisons of airborne water vapor lidar systems and allows very important conclusions to be drawn for future field campaigns.
Wulfmeyer, Volker, Ferrare, Richard, Ismail, Syed, Schaberl, Thorsten, Andreas Behrendt, Richard Ferrare, Whiteman, David N., Kooi, Susan, Ehret, Gerhard, Browell, Edward V., Kiemle, Christoph, Volker Wulfmeyer, Behrendt, Andreas, Christoph Kiemle, N. Whiteman, David, Gerhard Ehret, Syed Ismail, Flamant, Cyrille, Cyrille Flamant, Bauer, Hans-Stefan, Susan Kooi, Browell, E.-V., David N. Whiteman, Thorsten Schaberl, Edward V. Browell, Hans-Stefan Bauer   +25 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Tropical teleconnections through the Amundsen Sea Low impact Antarctic toothfish recruitment within the Ross Gyre

Scientific Reports
Antarctic toothfish (Dissostichus mawsoni) in the Ross Sea region are believed to spawn predominantly in the northern parts of the Ross Gyre during the austral winter with fluctuations in their recruitment observed.
Erik Behrens, Arnaud Grüss, Matt Pinkerton, Steve Parker, Graham Rickard, Craig Stevens   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

What We Do in the Shallows: Natural and Anthropogenic Seafloor Geomorphologies in a Drowned River Valley, New Zealand

Frontiers in Marine Science, 2020
The shallow marine environment represents a region of high biological productivity, ecological diversity, and complex oceanographic conditions, and often supports various human activities and industries.
Sally J. Watson, Helen Neil, Marta Ribó, Geoffroy Lamarche, Geoffroy Lamarche, Geoffroy Lamarche, Lorna J. Strachan, Kevin MacKay, Steve Wilcox, Tim Kane, Alan Orpin, Scott Nodder, Arne Pallentin, Tilmann Steinmetz   +13 more
doaj   +1 more source

Illinois Water and Climate Summary, 2000 [PDF]

, 2000
Submitted by Noor Syahira Nasarudin (nasarud2@illinois.edu) on 2015-01-23T20:21:38Z No. of bitstreams: 12 jan00.pdf: 615264 bytes, checksum: 740e84de79520ccb46b9b1b55f59cb48 (MD5) feb00.pdf: 371052 bytes, checksum: 335ac5be85b30290ad598f760589d80e (MD5 ...
Water and Atmospheric Resource Monitoring Program
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

National Atmospheric Deposition Program 2011 Annual summary [PDF]

, 2012
is peer reviewedSubmitted by Susan Braxton (braxton@illinois.edu) on 2013-01-29T22:55:31Z No. of bitstreams: 1 2011as.pdf: 4443124 bytes, checksum: 1e2ff568a6e350fe41bba46c81de3531 (MD5)Made available in DSpace on 2013-01-29T22:55:31Z (GMT). No.
National Atmospheric Deposition Program
core  

Constraining ecosystem processes from tower fluxes and atmospheric profiles [PDF]

, 2011
The planetary boundary layer (PBL) provides an important link between the scales and processes resolved by global atmospheric sampling/modeling and site-based flux measurements.
T. C. Hill, Moncrieff, J. B., M. Williams, F. I. Woodward, J. B. Moncrieff, Hill, T. C., Williams, M., Woodward, F. I., Williams, M.; id_orcid   +8 more
core   +1 more source